EFNA4 (ephrin A4)

2010-01-01  

Identity

HGNC
EFNA4
LOCATION
1q21.3
LOCUSID
1945
ALIAS
EFL4,EPLG4,LERK4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1945
MIM: 601380
HGNC: 3224
Ensembl: ENSG00000243364

Variants:

dbSNP: 1945
ClinVar: 1945
TCGA: ENSG00000243364
COSMIC: EFNA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000243364ENST00000359751P52798
ENSG00000243364ENST00000368409P52798
ENSG00000243364ENST00000427683P52798

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364044392022Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2.3
364044392022Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2.3
334367722021Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells.7
334367722021Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells.7
273741802016EphrinA4 plays a critical role in α4 and αL mediated survival of human CLL cells during extravasation.4
273741802016EphrinA4 plays a critical role in α4 and αL mediated survival of human CLL cells during extravasation.4
250709152014Ephrin-A3 and ephrin-A4 contribute to microglia-induced angiogenesis in brain endothelial cells.16
250709152014Ephrin-A3 and ephrin-A4 contribute to microglia-induced angiogenesis in brain endothelial cells.16
236868142013Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.6
236868142013Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells.6
200717902010Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome.6
206437272010Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis.87
200717902010Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome.6
206437272010Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis.87
188197112009Expression profile of Eph receptors and ephrin ligands in healthy human B lymphocytes and chronic lymphocytic leukemia B-cells.17

Citation

Dessen P

EFNA4 (ephrin A4)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51304/cancer-prone-explorer/css/lib/teaching-explorer/