LEAP2 (liver enriched antimicrobial peptide 2)

2010-03-01  

Identity

HGNC
LEAP2
LOCATION
5q31.1
LOCUSID
116842
ALIAS
LEAP-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 116842
MIM: 611373
HGNC: 29571
Ensembl: ENSG00000164406

Variants:

dbSNP: 116842
ClinVar: 116842
TCGA: ENSG00000164406
COSMIC: LEAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164406ENST00000296877Q969E1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157

References

Pubmed IDYearTitleCitations
374369622023LEAP2 is associated with cardiometabolic markers but is unchanged by antidiabetic treatment in people with prediabetes.1
374369622023LEAP2 is associated with cardiometabolic markers but is unchanged by antidiabetic treatment in people with prediabetes.1
360769122022Study of the Ghrelin/LEAP-2 Ratio in Humans and Rats during Different Phases of Pregnancy.4
360769122022Study of the Ghrelin/LEAP-2 Ratio in Humans and Rats during Different Phases of Pregnancy.4
331398872021Circulating LEAP-2 is associated with puberty in girls.13
338114782021Human liver-expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis.4
339661142021LEAP2 has antagonized the ghrelin receptor GHSR1a since its emergence in ancient fish.6
339911452021LEAP-2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study.5
331398872021Circulating LEAP-2 is associated with puberty in girls.13
338114782021Human liver-expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis.4
339661142021LEAP2 has antagonized the ghrelin receptor GHSR1a since its emergence in ancient fish.6
339911452021LEAP-2/ghrelin interplay in adult growth hormone deficiency: Cause or consequence? A pilot study.5
315260692020Decreased levels of liver-expressed antimicrobial peptide-2 and ghrelin are related to insulin resistance in women with polycystic ovary syndrome.5
317701062020Plasma levels of ghrelin, des-acyl ghrelin and LEAP2 in children with obesity: correlation with age and insulin resistance.20
322685202020Levels of the Novel Endogenous Antagonist of Ghrelin Receptor, Liver-Enriched Antimicrobial Peptide-2, in Patients with Rheumatoid Arthritis.10

Citation

Dessen P

LEAP2 (liver enriched antimicrobial peptide 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51383