SHOC2 (SHOC2 leucine rich repeat scaffold protein)

2010-03-01  

Identity

HGNC
SHOC2
LOCATION
10q25.2
LOCUSID
8036
ALIAS
NSLH1,SIAA0862,SOC2,SUR8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8036
MIM: 602775
HGNC: 15454
Ensembl: ENSG00000108061

Variants:

dbSNP: 8036
ClinVar: 8036
TCGA: ENSG00000108061
COSMIC: SHOC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108061ENST00000265277Q9UQ13
ENSG00000108061ENST00000369452Q9UQ13
ENSG00000108061ENST00000451838X6RI37

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ras signaling pathwayKEGGhsa04014

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382195332024circCPA4 induces malignant behaviors of prostate cancer via miR-491-5p/SHOC2 feedback loop.0
382195332024circCPA4 induces malignant behaviors of prostate cancer via miR-491-5p/SHOC2 feedback loop.0
371664212023LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis.1
371700832023SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus.0
377934912023Aberrant N-myristoylation as a prelude to autoimmune manifestations in patients with SHOC2 mutations.2
371664212023LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis.1
371700832023SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus.0
377934912023Aberrant N-myristoylation as a prelude to autoimmune manifestations in patients with SHOC2 mutations.2
353486762022Expanding the molecular spectrum of pathogenic SHOC2 variants underlying Mazzanti syndrome.5
357685042022Structural basis for SHOC2 modulation of RAS signalling.8
358226842022The Clinical and Molecular Assessment of Iranian Families with Severe Congenital Neutropenia, Identification of HYOU1 and SHOC2 as Potential Novel Gene Defects.0
358308822022Structure of the MRAS-SHOC2-PP1C phosphatase complex.7
358315092022Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.19
361756702022Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.11
364207062022lncRNA MALAT1 regulates the resistance of breast cancer cells to paclitaxel via the miR-497-5p/SHOC2 axis.6

Citation

Dessen P

SHOC2 (SHOC2 leucine rich repeat scaffold protein)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51395/js/lib/bootstrap.min.js