Identity
HGNC
LOCATION
10q25.2
LOCUSID
ALIAS
NSLH1,SIAA0862,SOC2,SUR8
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8036
MIM: 602775
HGNC: 15454
Ensembl: ENSG00000108061
Variants:
dbSNP: 8036
ClinVar: 8036
TCGA: ENSG00000108061
COSMIC: SHOC2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000108061 | ENST00000265277 | Q9UQ13 |
| ENSG00000108061 | ENST00000369452 | Q9UQ13 |
| ENSG00000108061 | ENST00000451838 | X6RI37 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Ras signaling pathway | KEGG | hsa04014 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38219533 | 2024 | circCPA4 induces malignant behaviors of prostate cancer via miR-491-5p/SHOC2 feedback loop. | 0 |
| 38219533 | 2024 | circCPA4 induces malignant behaviors of prostate cancer via miR-491-5p/SHOC2 feedback loop. | 0 |
| 37166421 | 2023 | LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis. | 1 |
| 37170083 | 2023 | SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus. | 0 |
| 37793491 | 2023 | Aberrant N-myristoylation as a prelude to autoimmune manifestations in patients with SHOC2 mutations. | 2 |
| 37166421 | 2023 | LncRNA FALEC increases the proliferation, migration and drug resistance of cholangiocarcinoma through competitive regulation of miR-20a-5p/SHOC2 axis. | 1 |
| 37170083 | 2023 | SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus. | 0 |
| 37793491 | 2023 | Aberrant N-myristoylation as a prelude to autoimmune manifestations in patients with SHOC2 mutations. | 2 |
| 35348676 | 2022 | Expanding the molecular spectrum of pathogenic SHOC2 variants underlying Mazzanti syndrome. | 5 |
| 35768504 | 2022 | Structural basis for SHOC2 modulation of RAS signalling. | 8 |
| 35822684 | 2022 | The Clinical and Molecular Assessment of Iranian Families with Severe Congenital Neutropenia, Identification of HYOU1 and SHOC2 as Potential Novel Gene Defects. | 0 |
| 35830882 | 2022 | Structure of the MRAS-SHOC2-PP1C phosphatase complex. | 7 |
| 35831509 | 2022 | Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. | 19 |
| 36175670 | 2022 | Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. | 11 |
| 36420706 | 2022 | lncRNA MALAT1 regulates the resistance of breast cancer cells to paclitaxel via the miR-497-5p/SHOC2 axis. | 6 |
Citation
Dessen P
SHOC2 (SHOC2 leucine rich repeat scaffold protein)
Atlas Genet Cytogenet Oncol Haematol. 2010-03-01
Online version: http://atlasgeneticsoncology.org/gene/51395/shoc2
