Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
Variants:
dbSNP: 7361
ClinVar: 7361
COSMIC: UGT1A
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166123346 | bilirubin | Chemical | ClinicalAnnotation | associated | PK | 25778466 | |
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation | associated | PK | PD | 25778466 |
| PA446443 | Liver Failure, Acute | Disease | ClinicalAnnotation | associated | PD | ||
| PA448015 | acetaminophen | Chemical | ClinicalAnnotation | associated | PK | PD | |
| PA450085 | irinotecan | Chemical | ClinicalAnnotation | associated | PD | 25778466 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37328712 | 2023 | The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis. | 1 |
| 37328712 | 2023 | The Activity of Members of the UDP-Glucuronosyltransferase Subfamilies UGT1A and UGT2B is Impaired in Patients with Liver Cirrhosis. | 1 |
| 33432840 | 2021 | Regulation of uridine diphosphate-glucuronosyltransferase 1A expression by miRNA-214-5p and miRNA-486-3p. | 2 |
| 33432840 | 2021 | Regulation of uridine diphosphate-glucuronosyltransferase 1A expression by miRNA-214-5p and miRNA-486-3p. | 2 |
| 29172698 | 2018 | Regulation of UGT1A expression by miR-298 in human livers from the Han Chinese population and in human cell lines. | 2 |
| 29210323 | 2018 | Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis. | 12 |
| 29172698 | 2018 | Regulation of UGT1A expression by miR-298 in human livers from the Han Chinese population and in human cell lines. | 2 |
| 29210323 | 2018 | Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis. | 12 |
| 28049773 | 2017 | Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism. | 12 |
| 28294511 | 2017 | UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population. | 7 |
| 28300668 | 2017 | Protective effects of coffee against oxidative stress induced by the tobacco carcinogen benzo[α]pyrene. | 11 |
| 28049773 | 2017 | Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism. | 12 |
| 28294511 | 2017 | UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population. | 7 |
| 28300668 | 2017 | Protective effects of coffee against oxidative stress induced by the tobacco carcinogen benzo[α]pyrene. | 11 |
| 26010150 | 2015 | Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients. | 9 |
Citation
Dessen P
UGT1A (UDP glucuronosyltransferase family 1 member A complex locus)
Atlas Genet Cytogenet Oncol Haematol. 2010-03-01
Online version: http://atlasgeneticsoncology.org/gene/51398/ugt1a
