TRIM22 (tripartite motif containing 22)

2010-03-01  

Identity

HGNC
TRIM22
LOCATION
11p15.4
LOCUSID
10346
ALIAS
GPSTAF50,RNF94,STAF50
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10346
MIM: 606559
HGNC: 16379
Ensembl: ENSG00000132274

Variants:

dbSNP: 10346
ClinVar: 10346
TCGA: ENSG00000132274
COSMIC: TRIM22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132274ENST00000379965Q8IYM9
ENSG00000132274ENST00000414641C9JIU5
ENSG00000132274ENST00000414897H7BZD3
ENSG00000132274ENST00000425490C9J060
ENSG00000132274ENST00000429063H7C376
ENSG00000132274ENST00000444844H7C262
ENSG00000132274ENST00000450670H7C2K0
ENSG00000132274ENST00000454828C9JWC5

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381999812024TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma.0
382752982024The E3 ligase TRIM22 restricts SARS-CoV-2 replication by promoting proteasomal degradation of NSP8.3
381999812024TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma.0
382752982024The E3 ligase TRIM22 restricts SARS-CoV-2 replication by promoting proteasomal degradation of NSP8.3
372585772023TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.4
372585772023TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.4
356360152022TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling.37
356741572022Role of TRIM22 in ulcerative colitis and its underlying mechanisms.1
359464622022FOXC1‑mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblast‑like synoviocytes in rheumatoid arthritis via NF‑κB signaling pathway.3
360289022022On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity.8
361704532022TRIM22 actives PI3K/Akt/mTOR pathway to promote psoriasis through enhancing cell proliferation and inflammation and inhibiting autophagy.2
356360152022TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling.37
356741572022Role of TRIM22 in ulcerative colitis and its underlying mechanisms.1
359464622022FOXC1‑mediated TRIM22 regulates the excessive proliferation and inflammation of fibroblast‑like synoviocytes in rheumatoid arthritis via NF‑κB signaling pathway.3
360289022022On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity.8

Citation

Dessen P

TRIM22 (tripartite motif containing 22)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51401/deep-insight-explorer/js/lib/popper.js