PTGER3 (prostaglandin E receptor 3)

2010-04-01  

Identity

HGNC
PTGER3
LOCATION
1p31.1
LOCUSID
5733
ALIAS
EP3,EP3-I,EP3-II,EP3-III,EP3-IV,EP3-VI,EP3e,PGE2-R,lnc003875
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5733
MIM: 176806
HGNC: 9595
Ensembl: ENSG00000050628

Variants:

dbSNP: 5733
ClinVar: 5733
TCGA: ENSG00000050628
COSMIC: PTGER3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000050628ENST00000306666P43115
ENSG00000050628ENST00000351052P43115
ENSG00000050628ENST00000354608F8WAJ7
ENSG00000050628ENST00000356595P43115
ENSG00000050628ENST00000361210O00325
ENSG00000050628ENST00000370924P43115
ENSG00000050628ENST00000370931P43115
ENSG00000050628ENST00000370932A0A0A0MRP3
ENSG00000050628ENST00000460330P43115
ENSG00000050628ENST00000479353P43115
ENSG00000050628ENST00000497146A0A0B4J204
ENSG00000050628ENST00000628037P43115

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Pathways in cancerKEGGhsa05200
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Regulation of lipolysis in adipocytesKEGGhsa04923
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Prostanoid ligand receptorsREACTOMER-HSA-391908
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164712308Ace Inhibitors, PlainChemicalClinicalAnnotationassociatedPD21052031
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD17496729
PA443803CoughDiseaseClinicalAnnotationassociatedPD21052031
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD21052031
PA448497aspirinChemicalClinicalAnnotationassociatedPD17496729

References

Pubmed IDYearTitleCitations
385665282024PTGER3 knockdown inhibits the vulnerability of triple-negative breast cancer to ferroptosis.1
385665282024PTGER3 knockdown inhibits the vulnerability of triple-negative breast cancer to ferroptosis.1
351137492023Altered Prostaglandin E Receptor Subtype 3 Expression in Lacrimal Glands of Patients with Chronic Stevens-Johnson Syndrome.0
365781052023E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation.1
351137492023Altered Prostaglandin E Receptor Subtype 3 Expression in Lacrimal Glands of Patients with Chronic Stevens-Johnson Syndrome.0
365781052023E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation.1
348228082022Prostaglandin E2 EP receptors in cardiovascular disease: An update.13
351348512022Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss.6
357818182022PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.2
348228082022Prostaglandin E2 EP receptors in cardiovascular disease: An update.13
351348512022Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss.6
357818182022PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.2
324884962020Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR).9
325802762020EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases.2
324884962020Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR).9

Citation

Dessen P

PTGER3 (prostaglandin E receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51416