Identity
HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
FFEVF2,NPR2,NPR2L,TUSC4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10641
MIM: 607072
HGNC: 24969
Ensembl: ENSG00000114388
Variants:
dbSNP: 10641
ClinVar: 10641
TCGA: ENSG00000114388
COSMIC: NPRL2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| mTOR signaling pathway | KEGG | ko04150 |
| mTOR signaling pathway | KEGG | hsa04150 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37121122 | 2023 | Risk signature identification and NPRL2 affects sunitinib sensitivity in clear cell renal cell carcinoma. | 0 |
| 37259768 | 2023 | Seizure features and outcomes in 50 children with GATOR1 variants: A retrospective study, more favorable for epilepsy surgery. | 2 |
| 37121122 | 2023 | Risk signature identification and NPRL2 affects sunitinib sensitivity in clear cell renal cell carcinoma. | 0 |
| 37259768 | 2023 | Seizure features and outcomes in 50 children with GATOR1 variants: A retrospective study, more favorable for epilepsy surgery. | 2 |
| 34376795 | 2022 | A splicing variation in NPRL2 causing familial focal epilepsy with variable foci: additional cases and literature review. | 3 |
| 35731010 | 2022 | Nitrogen Permease Regulator Like-2 (NPRL2 ) truncating mutation causes Ohtahara syndrome with incomplete penetrance: expanding the genotype-phenotype correlations. | 0 |
| 36321403 | 2022 | NPRL2 down-regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression. | 2 |
| 34376795 | 2022 | A splicing variation in NPRL2 causing familial focal epilepsy with variable foci: additional cases and literature review. | 3 |
| 35731010 | 2022 | Nitrogen Permease Regulator Like-2 (NPRL2 ) truncating mutation causes Ohtahara syndrome with incomplete penetrance: expanding the genotype-phenotype correlations. | 0 |
| 36321403 | 2022 | NPRL2 down-regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression. | 2 |
| 33905671 | 2021 | NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation. | 4 |
| 34459063 | 2021 | FOXO1 inhibits prostate cancer cell proliferation via suppressing E2F1 activated NPRL2 expression. | 7 |
| 33905671 | 2021 | NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation. | 4 |
| 34459063 | 2021 | FOXO1 inhibits prostate cancer cell proliferation via suppressing E2F1 activated NPRL2 expression. | 7 |
| 32234375 | 2020 | NPRL2 promotes docetaxel chemoresistance in castration resistant prostate cancer cells by regulating autophagy through the mTOR pathway. | 9 |
Citation
Dessen P
NPRL2 (NPR2 like, GATOR1 complex subunit)
Atlas Genet Cytogenet Oncol Haematol. 2010-04-01
Online version: http://atlasgeneticsoncology.org/gene/51431/nprl2
