Identity
HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
A-116A10.1,APPBP1,HPP1,ula-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8883
MIM: 603385
HGNC: 621
Ensembl: ENSG00000159593
Variants:
dbSNP: 8883
ClinVar: 8883
TCGA: ENSG00000159593
COSMIC: NAE1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Alzheimer's disease | KEGG | ko05010 |
| Alzheimer's disease | KEGG | hsa05010 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31002342 | 2019 | Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib. | 13 |
| 31002342 | 2019 | Inhibition of neddylation modification by MLN4924 sensitizes hepatocellular carcinoma cells to sorafenib. | 13 |
| 29233905 | 2018 | Neddylation Blockade Diminishes Hepatic Metastasis by Dampening Cancer Stem-Like Cells and Angiogenesis in Uveal Melanoma. | 35 |
| 29233905 | 2018 | Neddylation Blockade Diminishes Hepatic Metastasis by Dampening Cancer Stem-Like Cells and Angiogenesis in Uveal Melanoma. | 35 |
| 28535453 | 2017 | Inhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine. | 12 |
| 28535453 | 2017 | Inhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine. | 12 |
| 25229838 | 2014 | Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target. | 43 |
| 25229838 | 2014 | Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target. | 43 |
| 22182960 | 2012 | Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells. | 1 |
| 23185368 | 2012 | A metal-based inhibitor of NEDD8-activating enzyme. | 10 |
| 22182960 | 2012 | Amyloid precursor protein binding protein-1 knockdown reduces neuronal differentiation in fetal neural stem cells. | 1 |
| 23185368 | 2012 | A metal-based inhibitor of NEDD8-activating enzyme. | 10 |
| 19795456 | 2010 | Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. | 86 |
| 21151996 | 2010 | Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells. | 9 |
| 19795456 | 2010 | Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. | 86 |
Citation
Dessen P
NAE1 (NEDD8 activating enzyme E1 subunit 1)
Atlas Genet Cytogenet Oncol Haematol. 2010-04-01
Online version: http://atlasgeneticsoncology.org/gene/51436/nae1
