BTLA (B and T lymphocyte associated)

2010-04-01  

Identity

HGNC
BTLA
LOCATION
3q13.2
LOCUSID
151888
ALIAS
BTLA1,CD272

Other Information

Locus ID:

NCBI: 151888
MIM: 607925
HGNC: 21087
Ensembl: ENSG00000186265

Variants:

dbSNP: 151888
ClinVar: 151888
TCGA: ENSG00000186265
COSMIC: BTLA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186265ENST00000334529Q7Z6A9
ENSG00000186265ENST00000383680Q7Z6A9

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Costimulation by the CD28 familyREACTOMER-HSA-388841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384184882024BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4(+) T-cell exhaustion.0
389283072024The Immune Checkpoint BTLA in Oral Cancer: Expression Analysis and Its Correlation to Other Immune Modulators.0
384184882024BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4(+) T-cell exhaustion.0
389283072024The Immune Checkpoint BTLA in Oral Cancer: Expression Analysis and Its Correlation to Other Immune Modulators.0
370412262023BTLA dysregulation correlates with poor outcome and diminished T cell-mediated antitumor responses in chronic lymphocytic leukemia.4
376557512023B- and T-lymphocyte attenuator could be a new player in accelerated atherosclerosis associated with chronic kidney disease.0
370412262023BTLA dysregulation correlates with poor outcome and diminished T cell-mediated antitumor responses in chronic lymphocytic leukemia.4
376557512023B- and T-lymphocyte attenuator could be a new player in accelerated atherosclerosis associated with chronic kidney disease.0
351961502022Clinical Significance of BTLA and HVEM Expression on Circulating CD4(+) T and CD8(+) T Cells in Chronic Hepatitis B Virus Infection.4
355373222022The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases.10
359457552022The correlation of BTLA rs1982809 polymorphism with cancer susceptibility: A meta-analysis of 8634 participators.0
359585792022Early detection of soluble CD27, BTLA, and TIM-3 predicts the development of nosocomial infection in pediatric burn patients.4
360815082022BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM.10
365527852022Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2.6
367413702022The association of BTLA gene polymorphisms with non-small lung cancer risk in smokers and never-smokers.5

Citation

Dessen P

BTLA (B and T lymphocyte associated)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51441