USP47 (ubiquitin specific peptidase 47)

2010-05-01  

Identity

HGNC
LOCATION
11p15.3
LOCUSID
ALIAS
TRFP
FUSION GENES

Other Information

Locus ID:

NCBI: 55031
MIM: 614460
HGNC: 20076
Ensembl: ENSG00000170242

Variants:

dbSNP: 55031
ClinVar: 55031
TCGA: ENSG00000170242
COSMIC: USP47

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170242ENST00000339865Q96K76
ENSG00000170242ENST00000399455Q96K76
ENSG00000170242ENST00000527733Q96K76

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381041572024USP47 stabilizes YBX1 to promote the progression of acute myeloid leukemia.0
381041572024USP47 stabilizes YBX1 to promote the progression of acute myeloid leukemia.0
367498232023USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.3
370013792023Deubiquitinase USP47 attenuates virus-induced type I interferon signaling.3
377400022023Structural and functional characterization of USP47 reveals a hot spot for inhibitor design.0
377880922023USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis.6
367498232023USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.3
370013792023Deubiquitinase USP47 attenuates virus-induced type I interferon signaling.3
377400022023Structural and functional characterization of USP47 reveals a hot spot for inhibitor design.0
377880922023USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis.6
352546552022Ubiquitin specific peptidase 47 promotes proliferation of lung squamous cell carcinoma.2
352546552022Ubiquitin specific peptidase 47 promotes proliferation of lung squamous cell carcinoma.2
333979552021Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.30
340300412021USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide.14
333979552021Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.30

Citation

Dessen P

USP47 (ubiquitin specific peptidase 47)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51474/usp47