PI3 (peptidase inhibitor 3)

2010-05-01  

Identity

HGNC
PI3
LOCATION
20q13.12
LOCUSID
5266
ALIAS
ESI,SKALP,WAP3,WFDC14,cementoin
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5266
MIM: 182257
HGNC: 8947
Ensembl: ENSG00000124102

Variants:

dbSNP: 5266
ClinVar: 5266
TCGA: ENSG00000124102
COSMIC: PI3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124102ENST00000243924P19957

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Developmental BiologyREACTOMER-HSA-1266738
Antimicrobial peptidesREACTOMER-HSA-6803157
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
332715652021Evaluation of Elafin Immunohistochemical Expression as Marker of Cervical Cancer Severity.6
336797282021Elafin as a Predictive Biomarker of Acute Skin Graft-Versus-Host Disease After Haploidentical Stem Cell Transplantation Using Post-Transplant High-Dose Cyclophosphamide.8
341819522021Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency.8
332715652021Evaluation of Elafin Immunohistochemical Expression as Marker of Cervical Cancer Severity.6
336797282021Elafin as a Predictive Biomarker of Acute Skin Graft-Versus-Host Disease After Haploidentical Stem Cell Transplantation Using Post-Transplant High-Dose Cyclophosphamide.8
341819522021Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency.8
322873142020High circulating elafin levels are associated with Crohn's disease-associated intestinal strictures.14
324605952020Recombinant Human Elafin Ameliorates Chronic Hyperoxia-Induced Lung Injury by Inhibiting Nuclear Factor-Kappa B Signaling in Neonatal Mice.11
324854432020Upregulation of elafin expression in the fallopian tube of ectopic tubal pregnancies compared to the normal tubes.0
327645172020Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris.9
322873142020High circulating elafin levels are associated with Crohn's disease-associated intestinal strictures.14
324605952020Recombinant Human Elafin Ameliorates Chronic Hyperoxia-Induced Lung Injury by Inhibiting Nuclear Factor-Kappa B Signaling in Neonatal Mice.11
324854432020Upregulation of elafin expression in the fallopian tube of ectopic tubal pregnancies compared to the normal tubes.0
327645172020Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris.9
305201522019A potential contribution of trappin-2 to the development of vasculopathy in systemic sclerosis.2

Citation

Dessen P

PI3 (peptidase inhibitor 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51476