Identity
HGNC
LOCATION
7q32.1
LOCUSID
ALIAS
C7orf68,HIG-2,HIG2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29923
MIM: 617905
HGNC: 28859
Ensembl: ENSG00000135245
Variants:
dbSNP: 29923
ClinVar: 29923
TCGA: ENSG00000135245
COSMIC: HILPDA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000135245 | ENST00000257696 | Q9Y5L2 |
| ENSG00000135245 | ENST00000435296 | Q9Y5L2 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of lipids and lipoproteins | REACTOME | R-HSA-556833 |
| Lipid digestion, mobilization, and transport | REACTOME | R-HSA-73923 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38335255 | 2024 | Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma. | 2 |
| 38335255 | 2024 | Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma. | 2 |
| 36933274 | 2023 | IRF1 promotes the chondrogenesis of human adipose-derived stem cells through regulating HILPDA. | 1 |
| 36990128 | 2023 | Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis. | 0 |
| 37061197 | 2023 | HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia. | 7 |
| 37552373 | 2023 | HILPDA-mediated lipidomic remodelling promotes radiotherapy resistance in nasopharyngeal carcinoma by accelerating mitophagy. | 3 |
| 36933274 | 2023 | IRF1 promotes the chondrogenesis of human adipose-derived stem cells through regulating HILPDA. | 1 |
| 36990128 | 2023 | Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis. | 0 |
| 37061197 | 2023 | HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia. | 7 |
| 37552373 | 2023 | HILPDA-mediated lipidomic remodelling promotes radiotherapy resistance in nasopharyngeal carcinoma by accelerating mitophagy. | 3 |
| 32818550 | 2020 | Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer. | 11 |
| 32818550 | 2020 | Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer. | 11 |
| 30884788 | 2019 | Key Genes of Lipid Metabolism and WNT-Signaling Are Downregulated in Subcutaneous Adipose Tissue with Moderate Weight Loss. | 7 |
| 30962421 | 2019 | A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. | 344 |
| 31142329 | 2019 | Hypoxia-inducible gene 2 promotes the immune escape of hepatocellular carcinoma from nature killer cells through the interleukin-10-STAT3 signaling pathway. | 21 |
Citation
Dessen P
HILPDA (hypoxia inducible lipid droplet associated)
Atlas Genet Cytogenet Oncol Haematol. 2010-05-01
Online version: http://atlasgeneticsoncology.org/gene/51494/hilpda
