Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10365
MIM: 602016
HGNC: 6347
Ensembl: ENSG00000127528
Variants:
dbSNP: 10365
ClinVar: 10365
TCGA: ENSG00000127528
COSMIC: KLF2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000127528 | ENST00000248071 | Q9Y5W3 |
| ENSG00000127528 | ENST00000592003 | K7EJ60 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| FoxO signaling pathway | KEGG | hsa04068 |
| Fluid shear stress and atherosclerosis | KEGG | ko05418 |
| Fluid shear stress and atherosclerosis | KEGG | hsa05418 |
| Apelin signaling pathway | KEGG | hsa04371 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38099436 | 2024 | HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells. | 2 |
| 38373841 | 2024 | KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis. | 0 |
| 38741032 | 2024 | N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension. | 0 |
| 38099436 | 2024 | HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells. | 2 |
| 38373841 | 2024 | KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis. | 0 |
| 38741032 | 2024 | N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension. | 0 |
| 36343116 | 2023 | Downregulated KLF2 in polycythemia vera and essential thrombocythemia induces prothrombotic gene expression. | 1 |
| 36680456 | 2023 | Circ_0043256 upregulates KLF2 expression by absorbing miR-1206 to suppress the tumorigenesis of lung cancer. | 5 |
| 36693535 | 2023 | Down-regulation of KLF2 in lung fibroblasts is linked with COVID-19 immunofibrosis and restored by combined inhibition of NETs, JAK-1/2 and IL-6 signaling. | 8 |
| 36768805 | 2023 | Dysregulation of Krüppel-like Factor 2 and Myocyte Enhancer Factor 2D Drive Cardiac Microvascular Inflammation and Dysfunction in Diabetes. | 1 |
| 37251374 | 2023 | Krüppel-like factor 2: a central regulator of B cell differentiation and plasma cell homing. | 0 |
| 37381732 | 2023 | KLF2 regulates stemness of human mesenchymal stem cells by targeting FGFR3. | 0 |
| 37452271 | 2023 | Mechanism of tumor-derived extracellular vesicles in prostatic cancer progression through the circFMN2/KLF2/RNF128 axis. | 1 |
| 37610103 | 2023 | KLF2 transcription suppresses endometrial cancer cell proliferation, invasion, and migration through the inhibition of NPM1. | 0 |
| 37642902 | 2023 | KLF2 Regulates Neural Differentiation of Dental Pulp-derived Stem Cells by Modulating Autophagy and Mitophagy. | 3 |
Citation
Dessen P
KLF2 (Kruppel like factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2010-06-01
Online version: http://atlasgeneticsoncology.org/gene/51504/klf2
