Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4985
MIM: 165195
HGNC: 8153
Ensembl: ENSG00000116329
Variants:
dbSNP: 4985
ClinVar: 4985
TCGA: ENSG00000116329
COSMIC: OPRD1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000116329 | ENST00000234961 | P41143 |
| ENSG00000116329 | ENST00000621425 | D2CGC9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443309 | Alcoholism | Disease | ClinicalAnnotation | associated | PD | 22954510 | |
| PA444460 | Heroin Dependence | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 28692418 | |
| PA445043 | Opioid-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 23612435, 24126707, 30368523, 30549211 | |
| PA446878 | Cocaine-Related Disorders | Disease | ClinicalAnnotation | associated | PD | ||
| PA447218 | Sexual Dysfunctions, Psychological | Disease | ClinicalAnnotation | associated | PD | 30549211 | |
| PA448685 | buprenorphine | Chemical | ClinicalAnnotation | associated | PD | 23612435, 24126707, 30368523, 30549211 | |
| PA449072 | cocaine | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449599 | fentanyl | Chemical | ClinicalAnnotation | associated | PD | 30549211 | |
| PA450401 | methadone | Chemical | ClinicalAnnotation | associated | PK | PD | 31907389 |
| PA450588 | naltrexone | Chemical | ClinicalAnnotation | associated | PD | 22954510 | |
| PA450741 | oxycodone | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451735 | tramadol | Chemical | ClinicalAnnotation | associated | PD | 30549211 | |
| PA452618 | opioids | Chemical | ClinicalAnnotation | associated | |||
| PA452619 | heroin | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 28692418 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35908776 | 2022 | Hypomethylation of the opioid receptor delta 1 gene combined with high opioid receptor delta 1 protein levels indicates increased risk of gout. | 1 |
| 35908776 | 2022 | Hypomethylation of the opioid receptor delta 1 gene combined with high opioid receptor delta 1 protein levels indicates increased risk of gout. | 1 |
| 33506435 | 2021 | Association Study of Opioid Receptor Delta-Type 1 (OPRD1) Gene Variants with Nicotine Dependence in an Iranian Population. | 0 |
| 33953123 | 2021 | The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients. | 2 |
| 34407719 | 2021 | Differential expression and transcription factor binding associated with genotype at a pharmacogenetic variant in OPRD1. | 0 |
| 34638633 | 2021 | Opioid Addiction and Opioid Receptor Dimerization: Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling Pathways. | 4 |
| 34685631 | 2021 | Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway. | 5 |
| 33506435 | 2021 | Association Study of Opioid Receptor Delta-Type 1 (OPRD1) Gene Variants with Nicotine Dependence in an Iranian Population. | 0 |
| 33953123 | 2021 | The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients. | 2 |
| 34407719 | 2021 | Differential expression and transcription factor binding associated with genotype at a pharmacogenetic variant in OPRD1. | 0 |
| 34638633 | 2021 | Opioid Addiction and Opioid Receptor Dimerization: Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling Pathways. | 4 |
| 34685631 | 2021 | Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway. | 5 |
| 31907389 | 2020 | Genetic polymorphisms in the opioid receptor delta 1 (OPRD1) gene are associated with methadone dose in methadone maintenance treatment for heroin dependence. | 4 |
| 32228617 | 2020 | Role of miR-326 in neonatal hypoxic-ischemic brain damage pathogenesis through targeting of the δ-opioid receptor. | 0 |
| 31907389 | 2020 | Genetic polymorphisms in the opioid receptor delta 1 (OPRD1) gene are associated with methadone dose in methadone maintenance treatment for heroin dependence. | 4 |
Citation
Dessen P
OPRD1 (opioid receptor delta 1)
Atlas Genet Cytogenet Oncol Haematol. 2010-06-01
Online version: http://atlasgeneticsoncology.org/gene/51518/oprd1
