INHBE (inhibin subunit beta E)

2010-06-01  

Identity

HGNC
INHBE
LOCATION
12q13.3
LOCUSID
83729
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83729
MIM: 612031
HGNC: 24029
Ensembl: ENSG00000139269

Variants:

dbSNP: 83729
ClinVar: 83729
TCGA: ENSG00000139269
COSMIC: INHBE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139269ENST00000266646P58166
ENSG00000139269ENST00000547970F8VNP4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
TGF-beta signaling pathwayKEGGko04350
Cytokine-cytokine receptor interactionKEGGhsa04060
TGF-beta signaling pathwayKEGGhsa04350
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Activin signalingKEGGhsa_M00681
Activin signalingKEGGM00681
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Peptide hormone biosynthesisREACTOMER-HSA-209952
Glycoprotein hormonesREACTOMER-HSA-209822

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379225702023Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease.2
379225702023Identification and validation of INHBE and P4HA1 as hub genes in non-alcoholic fatty liver disease.2
345152602022The Significance of INHBE Expression in the Cancer Cells of Clear-Cell Renal Cell Carcinoma.3
358965312022Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity.14
359992172022Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.17
345152602022The Significance of INHBE Expression in the Cancer Cells of Clear-Cell Renal Cell Carcinoma.3
358965312022Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity.14
359992172022Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.17
295964632018Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples.22
295964632018Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples.22
250624512014Effects of recombinant activins on steroidogenesis in human granulosa-lutein cells.18
250624512014Effects of recombinant activins on steroidogenesis in human granulosa-lutein cells.18
235800132013The inhibin-βC subunit is down-regulated, while inhibin-βE is up-regulated by interferon-β1a in Ishikawa carcinoma cell line.4
235800132013The inhibin-βC subunit is down-regulated, while inhibin-βE is up-regulated by interferon-β1a in Ishikawa carcinoma cell line.4
200123052010Inhibin/activin-betaC and -betaE subunits in the Ishikawa human endometrial adenocarcinoma cell line.8

Citation

Dessen P

INHBE (inhibin subunit beta E)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51532/favicon/teaching-explorer/gene-fusions/?id=51532