Identity
HGNC
LOCATION
2q31.1
LOCUSID
ALIAS
CAMP-GEFII,CGEF2,EPAC,EPAC
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11069
MIM: 606058
HGNC: 16626
Ensembl: ENSG00000091428
Variants:
dbSNP: 11069
ClinVar: 11069
TCGA: ENSG00000091428
COSMIC: RAPGEF4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35834616 | 2022 | EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression. | 2 |
| 35834616 | 2022 | EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression. | 2 |
| 33298248 | 2021 | Epac: new emerging cAMP-binding protein. | 15 |
| 34205489 | 2021 | Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections. | 2 |
| 34512170 | 2021 | Pancreatic cancer-derived exosomal microRNA-19a induces β-cell dysfunction by targeting ADCY1 and EPAC2. | 9 |
| 34685730 | 2021 | Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis. | 0 |
| 33298248 | 2021 | Epac: new emerging cAMP-binding protein. | 15 |
| 34205489 | 2021 | Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections. | 2 |
| 34512170 | 2021 | Pancreatic cancer-derived exosomal microRNA-19a induces β-cell dysfunction by targeting ADCY1 and EPAC2. | 9 |
| 34685730 | 2021 | Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis. | 0 |
| 32905835 | 2020 | The Epac2 coding gene (RAPGEF4) rs3769219 polymorphism is associated with protection against major depressive disorder in the Chinese Han population. | 0 |
| 32905835 | 2020 | The Epac2 coding gene (RAPGEF4) rs3769219 polymorphism is associated with protection against major depressive disorder in the Chinese Han population. | 0 |
| 31099751 | 2019 | Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis. | 28 |
| 31099751 | 2019 | Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis. | 28 |
| 29417338 | 2018 | Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment. | 19 |
Citation
Dessen P
RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Atlas Genet Cytogenet Oncol Haematol. 2010-06-01
Online version: http://atlasgeneticsoncology.org/gene/51540/rapgef4
