OGT (O-linked N-acetylglucosamine (GlcNAc) transferase)

2010-06-01  

Identity

HGNC
OGT
LOCATION
Xq13.1
LOCUSID
8473
ALIAS
HINCUT-1,HRNT1,MRX106,O-GLCNAC,OGT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8473
MIM: 300255
HGNC: 8127
Ensembl: ENSG00000147162

Variants:

dbSNP: 8473
ClinVar: 8473
TCGA: ENSG00000147162
COSMIC: OGT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147162ENST00000373701O15294
ENSG00000147162ENST00000373719O15294
ENSG00000147162ENST00000444774C9JZL3

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Other types of O-glycan biosynthesisKEGGko00514
Other types of O-glycan biosynthesisKEGGhsa00514
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
Insulin resistanceKEGGhsa04931
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383457492024O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency.0
386659162024O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.0
388525042024Downregulation of O-GlcNAc transferase activity impairs basal autophagy and late endosome positioning under nutrient-rich conditions in human colon cells.0
383457492024O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency.0
386659162024O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.0
388525042024Downregulation of O-GlcNAc transferase activity impairs basal autophagy and late endosome positioning under nutrient-rich conditions in human colon cells.0
364423032023O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes.6
373536172023Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263.0
376531702023Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase.2
379074622023Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex.3
364423032023O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes.6
373536172023Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263.0
376531702023Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase.2
379074622023Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex.3
351906422022O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation.20

Citation

Dessen P

OGT (O-linked N-acetylglucosamine (GlcNAc) transferase)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51541