NPY5R (neuropeptide Y receptor Y5)

2010-08-01  

Identity

HGNC
NPY5R
LOCATION
4q32.2
LOCUSID
4889
ALIAS
NPY5-R,NPYR5,NPYY5-R

Other Information

Locus ID:

NCBI: 4889
MIM: 602001
HGNC: 7958
Ensembl: ENSG00000164129

Variants:

dbSNP: 4889
ClinVar: 4889
TCGA: ENSG00000164129
COSMIC: NPY5R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164129ENST00000338566Q15761
ENSG00000164129ENST00000506953Q15761
ENSG00000164129ENST00000515560Q15761

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
350933842022Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.2
356606382022Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor.1
350933842022Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.2
356606382022Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor.1
319996432020Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.15
319996432020Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.15
297633692018Adipose Y5R mRNA is higher in obese than non-obese humans and is correlated with obesity parameters.4
297633692018Adipose Y5R mRNA is higher in obese than non-obese humans and is correlated with obesity parameters.4
251322612015Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance.17
251322612015Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance.17
239004452014Genetic association analysis of 30 genes related to obesity in a European American population.44
239004452014Genetic association analysis of 30 genes related to obesity in a European American population.44
239329372013Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis.25
239329372013Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis.25
203322112010Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line.19

Citation

Dessen P

NPY5R (neuropeptide Y receptor Y5)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51584/js/js/web-card-_common.js