SLCO1B1 (solute carrier organic anion transporter family member 1B1)

2010-08-01  

Identity

HGNC
SLCO1B1
LOCATION
12p12.1
LOCUSID
10599
ALIAS
HBLRR,LST-1,LST1,OATP-C,OATP1B1,OATP2,OATPC,SLC21A6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10599
MIM: 604843
HGNC: 10959
Ensembl: ENSG00000134538

Variants:

dbSNP: 10599
ClinVar: 10599
TCGA: ENSG00000134538
COSMIC: SLCO1B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134538ENST00000256958Q9Y6L6
ENSG00000134538ENST00000256958A0A024RAU7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of organic anionsREACTOMER-HSA-879518
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Recycling of bile acids and saltsREACTOMER-HSA-159418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10034bosentanChemicalVipGeneassociated17496208
PA10251atazanavirChemicalDataAnnotationassociated
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD27234217
PA133950441hmg coa reductase inhibitorsChemicalClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, Pathway, VipGeneassociatedPKPD11134001, 11477075, 12670950, 15970799, 16014768, 17177112, 17620857, 18650507, 1092254, 12811365, 15116054, 15226675, 16103896, 16678544, 17015053, 17108811, 17473846, 18650507, 18794729, 21178985, 21243006, 21928084, 22668755, 23361102, 23436703, 23708174, 23930675, 24263182, 24595600, 24598718, 24810685, 25350695, 25446771, 25630984, 25673568, 26086347, 26367500, 28812116
PA134308647rosuvastatinChemicalClinicalAnnotation, DataAnnotation, LabelAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD16697742, 17473846, 17568401, 18794729, 22668755, 23930675, 25630984, 28812116
PA142650384pitavastatinChemicalClinicalAnnotation, LabelAnnotation, VipGeneassociatedPK16595711, 15159445, 20175818, 23007012
PA143414738atrasentanChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPK16513443
PA164712509Arsenic compoundsChemicalVipGeneassociated16479312
PA164742950olmesartanChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPK18641915
PA164743013caspofunginChemicalVipGeneassociated15716364
PA164748728mycophenolic acidChemicalClinicalAnnotationassociatedPK25163792
PA164749431gemtuzumab ozogamicinChemicalClinicalAnnotationassociatedPD22584460
PA164754789conjugated estrogensChemicalClinicalAnnotation, VariantAnnotationassociated11477075
PA164754992rocuroniumChemicalClinicalAnnotationassociatedPD25279974
PA165108401Acute coronary syndromeDiseaseClinicalAnnotationassociatedPK25935875
PA165110775SN-38ChemicalClinicalAnnotationassociatedPD18221820
PA165374673ticagrelorChemicalClinicalAnnotationassociatedPK25935875
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPKPD21142914, 21878834, 25163792
PA166115842UGT1A1*28HaplotypeLabelAnnotationassociated
PA166119041drug-induced liver injuryDiseaseClinicalAnnotation, VariantAnnotationambiguousPD22562052
PA166122590simeprevirChemicalLabelAnnotationassociated
PA166129446simvastatin acidChemicalClinicalAnnotationassociatedPK25446771, 26367500, 28350522, 29469964
PA166153643rs1801131VariantGuidelineAnnotationassociated
PA166153644rs1801133VariantGuidelineAnnotationassociated
PA166154547rs2306283VariantLabelAnnotationassociated
PA166154575rs4149032VariantLabelAnnotationassociated
PA166154579rs4149056VariantGuidelineAnnotation, LabelAnnotationassociated
PA166154581rs4149081VariantGuidelineAnnotationassociated
PA166154633rs11045879VariantGuidelineAnnotationassociated
PA166155721rs4148323VariantLabelAnnotationassociated
PA166156544rs2231142VariantLabelAnnotationassociated
PA166163391statin-related myopathyDiseaseClinicalAnnotationassociatedPD28812116
PA166163418rucaparibChemicalLabelAnnotationassociated
PA166163438elbasvir / grazoprevirChemicalLabelAnnotationassociated
PA166182348elagolixChemicalLabelAnnotationassociated
PA166183785amlodipine / atorvastatin / perindopril arginineChemicalLabelAnnotationassociated
PA166184379letermovirChemicalClinicalAnnotation, LabelAnnotationassociatedPK31022310
PA166184495ezetimibe / simvastatinChemicalLabelAnnotationassociated
PA166184498ezetimibe / rosuvastatinChemicalLabelAnnotationassociated
PA267ABCB1GeneDataAnnotationassociated
PA378NR1I2GeneDataAnnotationassociated
PA390ABCG2GeneDataAnnotationassociated
PA443560Breast NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD27234217, 30520341
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD18221820
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD21178985, 21928084, 24595600, 28812116
PA443797Coronary DiseaseDiseaseClinicalAnnotationassociatedPD22668755
PA443886Diabetes MellitusDiseaseClinicalAnnotationassociatedPD21178985, 21928084, 24595600, 28812116
PA443890Diabetes Mellitus, Type 2DiseaseClinicalAnnotationassociatedPD27271184
PA443899DiarrheaDiseaseClinicalAnnotationassociatedPD27533851
PA443937Drug ToxicityDiseaseVariantAnnotationassociatedPD
PA444516HypercholesterolemiaDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD17473846, 18781850, 18794729, 21178985, 21928084, 22016628, 22668755, 23263738, 23930675, 24595600, 25630984, 26334272, 26932749, 28812116
PA444760Leukemia, Myeloid, AcuteDiseaseClinicalAnnotationassociatedPD22584460, 26663398
PA444997Muscular DiseasesDiseaseClinicalAnnotationassociatedPKPD12811365, 15116054, 15226675, 16103896, 16678544, 17015053, 17108811, 17473846, 18650507, 18794729, 21243006, 21928084, 22668755, 23361102, 23708174, 23930675, 24263182, 24595600, 24598718, 25446771, 25630984, 25673568, 26086347, 26367500
PA445062NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPD18221820, 19390945, 25869015
PA445113NeutropeniaDiseaseVariantAnnotationnot associatedPD19390945
PA445549RhabdomyolysisDiseaseClinicalAnnotationassociatedPKPD12811365, 15116054, 15226675, 16103896, 16678544, 17015053, 17108811, 17473846, 18650507, 18794729, 21243006, 21928084, 22668755, 23361102, 23708174, 23930675, 24263182, 24595600, 24598718, 25446771, 25630984, 25673568, 26086347, 26367500
PA445846ThrombocytopeniaDiseaseClinicalAnnotationassociatedPD27533851
PA445941TuberculosisDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD21709081
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD19901119, 23233662, 23652803, 24712521, 25098908, 28525903, 29683944
PA447048Myopathy, Central CoreDiseaseClinicalAnnotationassociatedPKPD17108811, 18650507, 21243006, 25446771
PA447230HIV InfectionsDiseaseClinicalAnnotationassociatedPKPD32022294
PA447288Essential hypertensionDiseaseClinicalAnnotationassociatedPD
PA448422amprenavirChemicalClinicalAnnotationassociatedPK
PA448500atorvastatinChemicalClinicalAnnotation, GuidelineAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD15616150, 15970779, 10601278, 15970799, 16103896, 17473846, 18794729, 19374892, 19833260, 20040338, 21243006, 21928084, 22016628, 23263738, 23361102, 23876492, 26334272, 26932749
PA448897cerivastatinChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPD15970799
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD27234217
PA449177cytarabineChemicalClinicalAnnotationassociatedPD22584460, 26663398
PA449212daunorubicinChemicalClinicalAnnotationassociatedPD26663398
PA449383docetaxelChemicalClinicalAnnotationassociatedPD27234217
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD27234217
PA449456enalaprilChemicalClinicalAnnotation, VipGeneassociatedPD16627748
PA449476epirubicinChemicalClinicalAnnotationassociatedPD27234217
PA449552etoposideChemicalClinicalAnnotationassociatedPD26663398
PA449594fenofibrateChemicalLabelAnnotationassociated
PA449655fludarabineChemicalClinicalAnnotationassociatedPD22584460
PA449688fluvastatinChemicalClinicalAnnotation, GuidelineAnnotation, Pathway, VariantAnnotationambiguousPD18781850, 18794729
PA449961idarubicinChemicalClinicalAnnotationassociatedPD22584460
PA450085irinotecanChemicalClinicalAnnotation, VariantAnnotationambiguousPD18221820, 19390945, 25869015
PA450112isoniazidChemicalVariantAnnotationnot associatedPD
PA450264lopinavirChemicalClinicalAnnotationassociatedPKPD32022294
PA450272lovastatinChemicalClinicalAnnotation, Pathway, VariantAnnotation, VipGeneassociatedPKPD15616150, 10601278, 16103896, 26020121
PA450379mercaptopurineChemicalClinicalAnnotationassociatedPD29683944
PA450428methotrexateChemicalClinicalAnnotation, GuidelineAnnotation, MultilinkAnnotation, Pathway, VariantAnnotation, VipGeneassociatedPKPD11477075, 19901119, 21317831, 23233662, 23652803, 24712521, 25098908, 25999454, 28525903, 29683944
PA450526mitoxantroneChemicalClinicalAnnotationassociatedPD26663398
PA450566mycophenolate mofetilChemicalClinicalAnnotationassociatedPKPD21142914, 21878834
PA450600nateglinideChemicalClinicalAnnotation, PathwayassociatedPK18187595
PA450761paclitaxelChemicalVariantAnnotationassociatedPK30520341
PA451089pravastatinChemicalClinicalAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD15970799, 10601278, 12811365, 15116054, 15226675, 15864131, 15970799, 16103896, 16678544, 16722833, 17439540, 17622941, 18794729, 19776292, 19833260, 21851379, 25502615
PA451234repaglinideChemicalClinicalAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD18187595, 15961978, 18187595, 18854776, 21327909, 29748863
PA451250rifampinChemicalClinicalAnnotationassociatedPKPD19374892, 21709081, 22562052, 24420746
PA451283rosiglitazoneChemicalClinicalAnnotation, PathwayassociatedPD27271184
PA451363simvastatinChemicalClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGeneambiguousPKPD11134001, 11477075, 12670950, 15970799, 16014768, 17177112, 17620857, 18650507, 1092254, 17108811, 18650507, 18794729, 21243006, 22617227, 22668755, 23708174, 24598718, 24918167, 25446771
PA451799troglitazoneChemicalVipGeneassociated14977862
PA451848valsartanChemicalVipGeneassociated16678545
PA7000sorafenibChemicalClinicalAnnotationassociatedPD27533851

References

Pubmed IDYearTitleCitations
373555032024SLCO1B1 Polymorphisms are Associated with the Susceptibility to Pulmonary Tuberculosis in Chinese Females.0
382790972024Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population.0
384051392024The impact of SLCO1B1 rs4149056 on LDL-C target achievement after lipid lowering therapy optimization in men and women with familial hypercholesterolemia.2
385153402024Non-targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function.1
373555032024SLCO1B1 Polymorphisms are Associated with the Susceptibility to Pulmonary Tuberculosis in Chinese Females.0
382790972024Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population.0
384051392024The impact of SLCO1B1 rs4149056 on LDL-C target achievement after lipid lowering therapy optimization in men and women with familial hypercholesterolemia.2
385153402024Non-targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function.1
364782962023Effects of the SLCO1B1 A388G single nucleotide polymorphism on the development, clinical parameters, treatment, and survival of multiple myeloma cases in a Polish population.1
367794982023Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder.1
369641022023SLCO1B1 and SLCO1B3 genetic mutations in Taiwanese patients with Rotor syndrome.1
371013152023Effect of SLCO1B1 c.521T>C polymorphism on the lipid response to statins in people living with HIV on a boosted protease inhibitor-containing regimen.0
372212222023SLCO1B1*5 is protective against non-senile cataracts in cohort prescribed statins: analysis in a British-South Asian cohort.2
372221582023The frequency of major ABCG2, SLCO1B1 and CYP2C9 variants in Asian, Native Hawaiian and Pacific Islander women subgroups: implications for personalized statins dosing.0
374426062023Interaction of Human OATP1B1 with PDZK1 Is Required for Its Trafficking to the Hepatocyte Plasma Membrane.2

Citation

Dessen P

SLCO1B1 (solute carrier organic anion transporter family member 1B1)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51592/slco1b1