NAA40 (N-alpha-acetyltransferase 40, NatD catalytic subunit)

2010-08-01  

Identity

HGNC
NAA40
LOCATION
11q13.1
LOCUSID
79829
ALIAS
NAT11,NatD,PATT1,hNatD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79829
HGNC: 25845
Ensembl: ENSG00000110583

Variants:

dbSNP: 79829
ClinVar: 79829
TCGA: ENSG00000110583
COSMIC: NAA40

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110583ENST00000377793Q86UY6
ENSG00000110583ENST00000377793A0A024R5C6
ENSG00000110583ENST00000534965F5GY41
ENSG00000110583ENST00000539656F5H2C9
ENSG00000110583ENST00000542163Q86UY6
ENSG00000110583ENST00000544138F5GXF6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
350447622023Effects of Oncohistone Mutations and PTM Crosstalk on the N-Terminal Acetylation Activities of NatD.4
350447622023Effects of Oncohistone Mutations and PTM Crosstalk on the N-Terminal Acetylation Activities of NatD.4
308583582019NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression.24
308583582019NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression.24
290305872017NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression.47
290305872017NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression.47
266667502016Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway.28
266667502016Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway.28
242489122013Structure of Patt1 human proapoptotic histone acetyltransferase.1
242489122013Structure of Patt1 human proapoptotic histone acetyltransferase.1
219354422011The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4.63
219354422011The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4.63
196953382009Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells.27
196953382009Patt1, a novel protein acetyltransferase that is highly expressed in liver and downregulated in hepatocellular carcinoma, enhances apoptosis of hepatoma cells.27

Citation

Dessen P

NAA40 (N-alpha-acetyltransferase 40, NatD catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51594