SLX4 (SLX4 structure-specific endonuclease subunit)

2010-09-01  

Identity

HGNC
SLX4
LOCATION
16p13.3
LOCUSID
84464
ALIAS
BTBD12,FANCP,MUS312
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84464
MIM: 613278
HGNC: 23845
Ensembl: ENSG00000188827

Variants:

dbSNP: 84464
ClinVar: 84464
TCGA: ENSG00000188827
COSMIC: SLX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188827ENST00000294008Q8IY92

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Fanconi Anemia PathwayREACTOMER-HSA-6783310

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370590912023Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.8
370590912023Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.8
333475462021SLX4-XPF mediates DNA damage responses to replication stress induced by DNA-protein interactions.8
335967612021Coordinated roles of SLX4 and MutSβ in DNA repair and the maintenance of genome stability.13
339458292021PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells.1
342723852021Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage.9
347062242021RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair.5
333475462021SLX4-XPF mediates DNA damage responses to replication stress induced by DNA-protein interactions.8
335967612021Coordinated roles of SLX4 and MutSβ in DNA repair and the maintenance of genome stability.13
339458292021PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells.1
342723852021Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage.9
347062242021RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair.5
323988292020SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations.21
323988292020SLX4 interacts with RTEL1 to prevent transcription-mediated DNA replication perturbations.21
306922062019RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening.69

Citation

Dessen P

SLX4 (SLX4 structure-specific endonuclease subunit)

Atlas Genet Cytogenet Oncol Haematol. 2010-09-01

Online version: http://atlasgeneticsoncology.org/gene/51673