FERMT2 (FERM domain containing kindlin 2)

2010-10-01  

Identity

HGNC
FERMT2
LOCATION
14q22.1
LOCUSID
10979
ALIAS
KIND2,MIG2,PLEKHC1,UNC112,UNC112B,mig-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10979
MIM: 607746
HGNC: 15767
Ensembl: ENSG00000073712

Variants:

dbSNP: 10979
ClinVar: 10979
TCGA: ENSG00000073712
COSMIC: FERMT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073712ENST00000341590Q96AC1
ENSG00000073712ENST00000341590A0A024R687
ENSG00000073712ENST00000343279Q96AC1
ENSG00000073712ENST00000395631Q96AC1
ENSG00000073712ENST00000395631A0A024R687
ENSG00000073712ENST00000399304Q96AC1
ENSG00000073712ENST00000553373Q96AC1
ENSG00000073712ENST00000553663H0YJB6
ENSG00000073712ENST00000554152H0YJ34
ENSG00000073712ENST00000554288G3V3J0
ENSG00000073712ENST00000554712G3V281
ENSG00000073712ENST00000555692G3V5R2
ENSG00000073712ENST00000557562G3V379
ENSG00000073712ENST00000635305A0A0U1RRM8

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-extracellular matrix interactionsREACTOMER-HSA-446353

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373573492024FERMT2 upregulation in CAFs enhances EMT of OSCC and M2 macrophage polarization.1
380848372024Kindlin-2 regulates colonic cancer stem-like cells survival and self-renewal via Wnt/β-catenin mediated pathway.3
373573492024FERMT2 upregulation in CAFs enhances EMT of OSCC and M2 macrophage polarization.1
380848372024Kindlin-2 regulates colonic cancer stem-like cells survival and self-renewal via Wnt/β-catenin mediated pathway.3
371422182023Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.1
374805042023Kindlin-2 controls angiogenesis through modulating Notch1 signaling.1
371422182023Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.1
374805042023Kindlin-2 controls angiogenesis through modulating Notch1 signaling.1
354504132022Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System.2
355957292022Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression.4
364805372022Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer.3
354504132022Kindlin-2 Promotes Chondrogenesis and Ameliorates IL-1beta-Induced Inflammation in Chondrocytes Cocultured with BMSCs in the Direct Contact Coculture System.2
355957292022Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression.4
364805372022Alzheimer's risk factor FERMT2 promotes the progression of colorectal carcinoma via Wnt/β-catenin signaling pathway and contributes to the negative correlation between Alzheimer and cancer.3
331257082021miRNA-200c-3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts.16

Citation

Dessen P

FERMT2 (FERM domain containing kindlin 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51688/css/gene-explorer/