ZNF420 (zinc finger protein 420)

2010-10-01  

Identity

HGNC
ZNF420
LOCATION
19q13.12
LOCUSID
147923
ALIAS
APAK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 147923
MIM: 617216
HGNC: 20649
Ensembl: ENSG00000197050

Variants:

dbSNP: 147923
ClinVar: 147923
TCGA: ENSG00000197050
COSMIC: ZNF420

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197050ENST00000304239Q8TAQ5
ENSG00000197050ENST00000337995Q8TAQ5
ENSG00000197050ENST00000585862K7ESJ1
ENSG00000197050ENST00000587029K7ELF6
ENSG00000197050ENST00000587082K7EPG0
ENSG00000197050ENST00000589245K7EQC9
ENSG00000197050ENST00000589461K7EJW2
ENSG00000197050ENST00000590332K7ERS3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseREACTOMER-HSA-6803204

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
259619322016H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK.34
259619322016H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK.34
256914622015ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis.1
256914622015ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis.1
223340682012Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis.9
223340682012Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis.9
196296432010Differential regulation of Apak by various DNA damage signals.1
207130542010ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress.7
196296432010Differential regulation of Apak by various DNA damage signals.1
207130542010ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress.7
193774692009KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.57
193774692009KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.57

Citation

Dessen P

ZNF420 (zinc finger protein 420)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51718/znf420