TIMD4 (T cell immunoglobulin and mucin domain containing 4)

2010-10-01  

Identity

HGNC
LOCATION
5q33.3
LOCUSID
ALIAS
SMUCKLER,TIM4

Other Information

Locus ID:

NCBI: 91937
MIM: 610096
HGNC: 25132
Ensembl: ENSG00000145850

Variants:

dbSNP: 91937
ClinVar: 91937
TCGA: ENSG00000145850
COSMIC: TIMD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145850ENST00000274532Q96H15
ENSG00000145850ENST00000406964B5MCV9
ENSG00000145850ENST00000407087Q96H15

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
368060502023TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis.5
368060502023TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis.5
328821422022Overexpression of Nuclear Enriched Autosomal Transcript 1 Facilitates Cell Proliferation, Migration Invasion, and Suppresses Apoptosis in Endometrial Cancer by Targeting MicroRNA-202-3p/T Cell Immunoglobulin and Mucin Domain 4 Axis.8
359906212022TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1-mediated epithelial to mesenchymal transition in nasal epithelial cells.8
328821422022Overexpression of Nuclear Enriched Autosomal Transcript 1 Facilitates Cell Proliferation, Migration Invasion, and Suppresses Apoptosis in Endometrial Cancer by Targeting MicroRNA-202-3p/T Cell Immunoglobulin and Mucin Domain 4 Axis.8
359906212022TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1-mediated epithelial to mesenchymal transition in nasal epithelial cells.8
333454582021Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays.6
334653922021Tim-4 expressing monocytes as a novel indicator to assess disease activity and severity of ulcerative colitis.3
335672752021Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation.9
340674572021EphA2 Interacts with Tim-4 through Association between Its FN3 Domain and the IgV Domain of Tim-4.0
341159892021Tim-4(+) cavity-resident macrophages impair anti-tumor CD8(+) T cell immunity.70
333454582021Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays.6
334653922021Tim-4 expressing monocytes as a novel indicator to assess disease activity and severity of ulcerative colitis.3
335672752021Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation.9
340674572021EphA2 Interacts with Tim-4 through Association between Its FN3 Domain and the IgV Domain of Tim-4.0

Citation

Dessen P

TIMD4 (T cell immunoglobulin and mucin domain containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51733/timd4