CHRNA9 (cholinergic receptor nicotinic alpha 9 subunit)

2010-10-01  

Identity

HGNC
CHRNA9
LOCATION
4p14
LOCUSID
55584
ALIAS
HSA243342,NACHRA9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55584
MIM: 605116
HGNC: 14079
Ensembl: ENSG00000174343

Variants:

dbSNP: 55584
ClinVar: 55584
TCGA: ENSG00000174343
COSMIC: CHRNA9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174343ENST00000310169Q9UGM1

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Acetylcholine Binding And Downstream EventsREACTOMER-HSA-181431
Activation of Nicotinic Acetylcholine ReceptorsREACTOMER-HSA-629602
Postsynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-622327
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-629594

References

Pubmed IDYearTitleCitations
329290052020Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products.9
329290052020Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products.9
286622952018α9-containing nicotinic acetylcholine receptors and the modulation of pain.45
286622952018α9-containing nicotinic acetylcholine receptors and the modulation of pain.45
282235282017Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.89
284083002017α9-nAChR knockout mice exhibit dysregulation of stress responses, affect and reward-related behaviour.13
282235282017Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.89
284083002017α9-nAChR knockout mice exhibit dysregulation of stress responses, affect and reward-related behaviour.13
273492882016Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors.53
273492882016Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors.53
254502292015The contribution of rare and common variants in 30 genes to risk nicotine dependence.0
254502292015The contribution of rare and common variants in 30 genes to risk nicotine dependence.0
246769962014Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9) polymorphisms are associated with NSCLC risk in a Chinese population.5
251429732014CHRNA9 polymorphisms and smoking exposure synergize to increase the risk of breast cancer in Taiwan.10
246769962014Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9) polymorphisms are associated with NSCLC risk in a Chinese population.5

Citation

Dessen P

CHRNA9 (cholinergic receptor nicotinic alpha 9 subunit)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51743