YTHDC1 (YTH domain containing 1)

2010-11-01  

Identity

HGNC
YTHDC1
LOCATION
4q13.2
LOCUSID
91746
ALIAS
YT521,YT521-B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 91746
MIM: 617283
HGNC: 30626
Ensembl: ENSG00000083896

Variants:

dbSNP: 91746
ClinVar: 91746
TCGA: ENSG00000083896
COSMIC: YTHDC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000083896ENST00000344157Q96MU7
ENSG00000083896ENST00000355665Q96MU7
ENSG00000083896ENST00000505251J3KS01
ENSG00000083896ENST00000507529J3KRG5
ENSG00000083896ENST00000510746J3KRW0
ENSG00000083896ENST00000579690J3QR07

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379173282024Recruitment of PVT1 Enhances YTHDC1-Mediated m6A Modification of IL-33 in Hyperoxia-Induced Lung Injury During Bronchopulmonary Dysplasia.2
382248632024KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.0
385665542024YTHDC1-dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple-negative breast cancer.1
385735282024YTHDC1 promotes the malignant progression of gastric cancer by promoting ROD1 translocation to the nucleus.0
387451922024KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m(6)A reader YTHDC1 protein degradation.1
379173282024Recruitment of PVT1 Enhances YTHDC1-Mediated m6A Modification of IL-33 in Hyperoxia-Induced Lung Injury During Bronchopulmonary Dysplasia.2
382248632024KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.0
385665542024YTHDC1-dependent m6A modification modulated FOXM1 promotes glycolysis and tumor progression through CENPA in triple-negative breast cancer.1
385735282024YTHDC1 promotes the malignant progression of gastric cancer by promoting ROD1 translocation to the nucleus.0
387451922024KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m(6)A reader YTHDC1 protein degradation.1
363024532023Downregulation of the m(6)A reader protein YTHDC1 leads to islet β-cell failure and diabetes.6
367809892023YTHDC1 maintains trophoblasts function by promoting degradation of m6A-modified circMPP1.3
368197852023The Effect of N6-Methyladenosine Regulators and m6A Reader YTHDC1-Mediated N6-Methyladenosine Modification Is Involved in Oxidative Stress in Human Aortic Dissection.2
368783222023Reduction of mRNA m(6)A associates with glucose metabolism via YTHDC1 in human and mice.4
369062052023Alternative splicing of HOXB-AS3 underlie the promoting effect of nuclear m6A reader YTHDC1 on the self-renewal of leukemic stem cells in acute myeloid leukemia.7

Citation

Dessen P

YTHDC1 (YTH domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51760/case-report-explorer/gene-fusions-explorer/