BAG6 (BAG cochaperone 6)

2010-12-01  

Identity

HGNC
BAG6
LOCATION
6p21.33
LOCUSID
7917
ALIAS
BAG-6,BAT3,D6S52E,G3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7917
MIM: 142590
HGNC: 13919
Ensembl: ENSG00000204463

Variants:

dbSNP: 7917
ClinVar: 7917
TCGA: ENSG00000204463
COSMIC: BAG6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204463ENST00000211379P46379
ENSG00000204463ENST00000211379A0A1U9X7A6
ENSG00000204463ENST00000362049P46379
ENSG00000204463ENST00000375964P46379
ENSG00000204463ENST00000375976P46379
ENSG00000204463ENST00000375976A0A1U9X7A6
ENSG00000204463ENST00000422948H0Y4L1
ENSG00000204463ENST00000424176F6XTU0
ENSG00000204463ENST00000424480F6VEM6
ENSG00000204463ENST00000428326F6U341
ENSG00000204463ENST00000433828F6X9W3
ENSG00000204463ENST00000434444F6WML8
ENSG00000204463ENST00000435080F6S6P2
ENSG00000204463ENST00000437771X6REW1
ENSG00000204463ENST00000438149H0Y759
ENSG00000204463ENST00000439687P46379
ENSG00000204463ENST00000441054F6U1F2
ENSG00000204463ENST00000441793H0Y710
ENSG00000204463ENST00000451898A0A1B0GX79
ENSG00000204463ENST00000452994F6U341
ENSG00000204463ENST00000453833H0Y7K4
ENSG00000204463ENST00000454165F6TC96
ENSG00000204463ENST00000456286F6UR09
ENSG00000204463ENST00000456622F6WML8

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448785carbamazepineChemicalClinicalAnnotationassociatedPD16538176

References

Pubmed IDYearTitleCitations
378156982024DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma.0
378156982024DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma.0
347043382022GET4 is a novel driver gene in colorectal cancer that regulates the localization of BAG6, a nucleocytoplasmic shuttling protein.5
355431562022Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex.1
347043382022GET4 is a novel driver gene in colorectal cancer that regulates the localization of BAG6, a nucleocytoplasmic shuttling protein.5
355431562022Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex.1
335220172021BAG6 promotes PINK1 signaling pathway and is essential for mitophagy.10
335392672021Association Between eNOS, MMP-9, BAG-6 Gene Polymorphisms and Risk of Hypertensive Disorders of Pregnancy in the Northern Chinese Population.1
336718362021Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in Contrast to BAG6 Only Marginally Released via Extracellular Vesicles.7
335220172021BAG6 promotes PINK1 signaling pathway and is essential for mitophagy.10
335392672021Association Between eNOS, MMP-9, BAG-6 Gene Polymorphisms and Risk of Hypertensive Disorders of Pregnancy in the Northern Chinese Population.1
336718362021Secreted Ligands of the NK Cell Receptor NKp30: B7-H6 Is in Contrast to BAG6 Only Marginally Released via Extracellular Vesicles.7
316475452020HLA-B-associated transcript 3 (Bat3) stabilizes and activates p53 in a HAUSP-dependent manner.2
318380602020BAG6 is a novel microtubule-binding protein that regulates ciliogenesis by modulating the cell cycle and interacting with γ-tubulin.3
319048422020PAQR9 Modulates BAG6-mediated protein quality control of mislocalized membrane proteins.2

Citation

Dessen P

BAG6 (BAG cochaperone 6)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51841