KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2)

2011-01-01  

Identity

HGNC
LOCATION
21q22.11
LOCUSID
ALIAS
ATFB4,LQT5,LQT6,MIRP1
FUSION GENES

Other Information

Locus ID:

NCBI: 9992
MIM: 603796
HGNC: 6242
Ensembl: ENSG00000159197

Variants:

dbSNP: 9992
ClinVar: 9992
TCGA: ENSG00000159197
COSMIC: KCNE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159197ENST00000290310Q9Y6J6

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 2 - plateau phaseREACTOMER-HSA-5576893
Phase 3 - rapid repolarisationREACTOMER-HSA-5576890

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
310445662019miR-584-5p regulates hepatocellular carcinoma cell migration and invasion through targeting KCNE2.11
312709662019The research of ion channel-related gene polymorphisms with atrial fibrillation in the Chinese Han population.3
316794572019A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity.4
310445662019miR-584-5p regulates hepatocellular carcinoma cell migration and invasion through targeting KCNE2.11
312709662019The research of ion channel-related gene polymorphisms with atrial fibrillation in the Chinese Han population.3
316794572019A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity.4
282800052017Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus.18
287940822017Loss-of-Function KCNE2 Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?15
282800052017Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus.18
287940822017Loss-of-Function KCNE2 Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?15
269564952016Filamin C: a novel component of the KCNE2 interactome during hypoxia.3
269564952016Filamin C: a novel component of the KCNE2 interactome during hypoxia.3
261237442015The KCNE2 K⁺ channel regulatory subunit: Ubiquitous influence, complex pathobiology.34
261237442015The KCNE2 K⁺ channel regulatory subunit: Ubiquitous influence, complex pathobiology.34
244608072014Single nucleotide polymorphisms in proximity to K-channel genes are associated with decreased longitudinal QTc variance.1

Citation

Dessen P

KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-01-01

Online version: http://atlasgeneticsoncology.org/gene/51948/kcne2