SP7 (Sp7 transcription factor)

2011-02-01  

Identity

HGNC
SP7
LOCATION
12q13.13
LOCUSID
121340
ALIAS
OI11,OI12,OSX,osterix

Other Information

Locus ID:

NCBI: 121340
MIM: 606633
HGNC: 17321
Ensembl: ENSG00000170374

Variants:

dbSNP: 121340
ClinVar: 121340
TCGA: ENSG00000170374
COSMIC: SP7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170374ENST00000303846Q8TDD2
ENSG00000170374ENST00000536324Q8TDD2
ENSG00000170374ENST00000537210A0A024RAY8
ENSG00000170374ENST00000547755F8VV67

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380703242024LncRNA urothelial cancer associated 1 promotes the osteogenic differentiation of human periodontal ligament stem cells by regulating the miR-96-5p/Osx axis.0
380703242024LncRNA urothelial cancer associated 1 promotes the osteogenic differentiation of human periodontal ligament stem cells by regulating the miR-96-5p/Osx axis.0
366729412023Epigenetic Repression of RUNX2 and OSX Promoters Controls the Nonmineralized State of the Periodontal Ligament.2
368812652023SP7: from Bone Development to Skeletal Disease.3
366729412023Epigenetic Repression of RUNX2 and OSX Promoters Controls the Nonmineralized State of the Periodontal Ligament.2
368812652023SP7: from Bone Development to Skeletal Disease.3
344562842022Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promotes the Osteoblast Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Targeting the microRNA-96/Osterix Axis.6
353674062022Dominant osteogenesis imperfecta with low bone turnover caused by a heterozygous SP7 variant.7
355380622022Klotho in Osx(+)-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair.11
356284562022Sp7 Action in the Skeleton: Its Mode of Action, Functions, and Relevance to Skeletal Diseases.12
344562842022Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promotes the Osteoblast Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Targeting the microRNA-96/Osterix Axis.6
353674062022Dominant osteogenesis imperfecta with low bone turnover caused by a heterozygous SP7 variant.7
355380622022Klotho in Osx(+)-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair.11
356284562022Sp7 Action in the Skeleton: Its Mode of Action, Functions, and Relevance to Skeletal Diseases.12
347253462021Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.35

Citation

Dessen P

SP7 (Sp7 transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52051