P2RX1 (purinergic receptor P2X 1)

2011-02-01  

Identity

HGNC
P2RX1
LOCATION
17p13.2
LOCUSID
5023
ALIAS
P2X1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5023
MIM: 600845
HGNC: 8533
Ensembl: ENSG00000108405

Variants:

dbSNP: 5023
ClinVar: 5023
TCGA: ENSG00000108405
COSMIC: P2RX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108405ENST00000225538P51575
ENSG00000108405ENST00000571637I3L3H3

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Platelet activationKEGGhsa04611
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
364183762023P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways.1
370461192023P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway.2
364183762023P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways.1
370461192023P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway.2
328052572020Functional expression of P2X1, P2X4 and P2X7 purinergic receptors in human monocyte-derived macrophages.9
328052572020Functional expression of P2X1, P2X4 and P2X7 purinergic receptors in human monocyte-derived macrophages.9
311641452019Toxoplasma gondii ROP18 inhibits human glioblastoma cell apoptosis through a mitochondrial pathway by targeting host cell P2X1.8
315914252019Shiga toxin signals via ATP and its effect is blocked by purinergic receptor antagonism.6
311641452019Toxoplasma gondii ROP18 inhibits human glioblastoma cell apoptosis through a mitochondrial pathway by targeting host cell P2X1.8
315914252019Shiga toxin signals via ATP and its effect is blocked by purinergic receptor antagonism.6
294433732018P2X1 Receptors Amplify FcγRIIa-Induced Ca2+ Increases and Functional Responses in Human Platelets.2
299972542018Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region.9
294433732018P2X1 Receptors Amplify FcγRIIa-Induced Ca2+ Increases and Functional Responses in Human Platelets.2
299972542018Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region.9
271835852016Impaired P2X1 Receptor-Mediated Adhesion in Eosinophils from Asthmatic Patients.10

Citation

Dessen P

P2RX1 (purinergic receptor P2X 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52052