PIWIL4 (piwi like RNA-mediated gene silencing 4)

2011-02-01  

Identity

HGNC
LOCATION
11q21
LOCUSID
ALIAS
HIWI2,MIWI2
FUSION GENES

Other Information

Locus ID:

NCBI: 143689
MIM: 610315
HGNC: 18444
Ensembl: ENSG00000134627

Variants:

dbSNP: 143689
ClinVar: 143689
TCGA: ENSG00000134627
COSMIC: PIWIL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134627ENST00000299001Q7Z3Z4
ENSG00000134627ENST00000299001A0A140VKG8
ENSG00000134627ENST00000446230Q7Z3Z4
ENSG00000134627ENST00000537419F5H116
ENSG00000134627ENST00000543336Q7Z3Z4
ENSG00000134627ENST00000545603F5GX26

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Dorso-ventral axis formationKEGGko04320
Dorso-ventral axis formationKEGGhsa04320
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
PIWI-interacting RNA (piRNA) biogenesisREACTOMER-HSA-5601884

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371462392023A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML.1
371462392023A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML.1
350744062022HIWI2 induces G2/M cell cycle arrest and apoptosis in human fibrosarcoma via the ROS/DNA damage/p53 axis.3
350744062022HIWI2 induces G2/M cell cycle arrest and apoptosis in human fibrosarcoma via the ROS/DNA damage/p53 axis.3
321611742020PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.8
323727242020Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells.7
321611742020PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.8
323727242020Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells.7
302265412018The role of 17β‑estradiol‑induced upregulation of Piwi‑like 4 in modulating gene expression and motility in breast cancer cells.5
302265412018The role of 17β‑estradiol‑induced upregulation of Piwi‑like 4 in modulating gene expression and motility in breast cancer cells.5
278940762017Co-expression of Piwil2/Piwil4 in nucleus indicates poor prognosis of hepatocellular carcinoma.9
280257952017Possible role of HIWI2 in modulating tight junction proteins in retinal pigment epithelial cells through Akt signaling pathway.8
288611072017PIWI-like protein, HIWI2 is aberrantly expressed in retinoblastoma cells and affects cell-cycle potentially through OTX2.9
289209252017Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells.10
278940762017Co-expression of Piwil2/Piwil4 in nucleus indicates poor prognosis of hepatocellular carcinoma.9

Citation

Dessen P

PIWIL4 (piwi like RNA-mediated gene silencing 4)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52078/piwil4