P2RX4 (purinergic receptor P2X 4)

2011-02-01  

Identity

HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
P2X4,P2X4R
FUSION GENES

Other Information

Locus ID:

NCBI: 5025
MIM: 600846
HGNC: 8535
Ensembl: ENSG00000135124

Variants:

dbSNP: 5025
ClinVar: 5025
TCGA: ENSG00000135124
COSMIC: P2RX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135124ENST00000337233Q99571
ENSG00000135124ENST00000359949Q99571
ENSG00000135124ENST00000538417H0YF70
ENSG00000135124ENST00000538701F5H1M6
ENSG00000135124ENST00000542067Q99571
ENSG00000135124ENST00000543171F6SFZ6
ENSG00000135124ENST00000543318F5GZQ9
ENSG00000135124ENST00000543984F5H2S3

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
387407822024P2X7R and P2X4R expression of mice submandibular gland in high-fat diet/streptozotocin-induced type 2 diabetes.0
387407822024P2X7R and P2X4R expression of mice submandibular gland in high-fat diet/streptozotocin-induced type 2 diabetes.0
371665842023Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy.0
371665842023Expression in skin biopsies supports genetic evidence linking CAMKK2, P2X7R and P2X4R with HIV-associated sensory neuropathy.0
353524882022Activation of P2X4 receptor exacerbates acute brain injury after intracerebral hemorrhage.7
356766842022Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation.6
363855252022Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation.22
353524882022Activation of P2X4 receptor exacerbates acute brain injury after intracerebral hemorrhage.7
356766842022Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation.6
363855252022Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation.22
338381192021Immunohistochemical evidence of P2X7R, P2X4R and CaMKK2 in pyramidal neurons of frontal cortex does not align with Alzheimer's disease.2
344047632021Lysosome purinergic receptor P2X4 regulates neoangiogenesis induced by microvesicles from sarcoma patients.12
344710062021[Elucidation of Mast Cell Activation Mechanism Mediated by Purinergic Signaling].0
346388322021P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H(1) Histamine Receptors.2
338381192021Immunohistochemical evidence of P2X7R, P2X4R and CaMKK2 in pyramidal neurons of frontal cortex does not align with Alzheimer's disease.2

Citation

Dessen P

P2RX4 (purinergic receptor P2X 4)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52083/p2rx4