DDX39A (DExD-box helicase 39A)

2011-02-01  

Identity

HGNC
DDX39A
LOCATION
19p13.12
LOCUSID
10212
ALIAS
BAT1,BAT1L,DDX39,DDXL,URH49
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10212
HGNC: 17821
Ensembl: ENSG00000123136

Variants:

dbSNP: 10212
ClinVar: 10212
TCGA: ENSG00000123136
COSMIC: DDX39A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123136ENST00000242776O00148
ENSG00000123136ENST00000324340O00148
ENSG00000123136ENST00000454233O00148
ENSG00000123136ENST00000586993K7EIL8
ENSG00000123136ENST00000588692O00148
ENSG00000123136ENST00000589675K7EQN7
ENSG00000123136ENST00000590239K7EN69
ENSG00000123136ENST00000590315K7EPJ3
ENSG00000123136ENST00000590696K7ENP6
ENSG00000123136ENST00000591275K7EL56
ENSG00000123136ENST00000592927A0A0D9SEM9

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382252622024Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.2
383779422024Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export.0
382252622024Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes.2
383779422024Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export.0
339416172021The Mammalian Ecdysoneless Protein Interacts with RNA Helicase DDX39A To Regulate Nuclear mRNA Export.4
344213572021DDX39 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with clear cell renal cell carcinoma.10
339416172021The Mammalian Ecdysoneless Protein Interacts with RNA Helicase DDX39A To Regulate Nuclear mRNA Export.4
344213572021DDX39 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with clear cell renal cell carcinoma.10
319173632020URH49 exports mRNA by remodeling complex formation and mediating the NXF1-dependent pathway.5
323935122020SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.14
319173632020URH49 exports mRNA by remodeling complex formation and mediating the NXF1-dependent pathway.5
323935122020SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.14
298671382018DDX39 promotes hepatocellular carcinoma growth and metastasis through activating Wnt/β-catenin pathway.33
298671382018DDX39 promotes hepatocellular carcinoma growth and metastasis through activating Wnt/β-catenin pathway.33
280251392017The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation.34

Citation

Dessen P

DDX39A (DExD-box helicase 39A)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52088/gene-fusions/img/tumors-explorer/