MED25 (mediator complex subunit 25)

2011-03-01  

Identity

HGNC
MED25
LOCATION
19q13.33
LOCUSID
81857
ALIAS
ACID1,ARC92,BVSYS,CMT2B2,P78,PTOV2,TCBAP0758
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81857
MIM: 610197
HGNC: 28845
Ensembl: ENSG00000104973

Variants:

dbSNP: 81857
ClinVar: 81857
TCGA: ENSG00000104973
COSMIC: MED25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104973ENST00000312865Q71SY5
ENSG00000104973ENST00000538643Q71SY5
ENSG00000104973ENST00000593767M0QZQ2
ENSG00000104973ENST00000595185M0QYR4
ENSG00000104973ENST00000612791A0A087WW16
ENSG00000104973ENST00000612854A0A087WYW9
ENSG00000104973ENST00000617849B9TX31
ENSG00000104973ENST00000618715B9TX31
ENSG00000104973ENST00000620467B9TX33
ENSG00000104973ENST00000622402A0A087WTR5

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361026482022An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25.3
361026482022An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25.3
328161212021Improving the phenotype description of Basel-Vanagaite-Smirin-Yosef syndrome, MED25-related: polymicrogyria as a distinctive neuroradiological finding.1
328161212021Improving the phenotype description of Basel-Vanagaite-Smirin-Yosef syndrome, MED25-related: polymicrogyria as a distinctive neuroradiological finding.1
323243102020Further delineation of Basel-Vanagaite-Smirin-Yosef syndrome: Report of three patients.2
323675062020Analysis of P(78): A Novel Cytoplasmic Membrane-Associated Protein Encoded on Chromosome 19q13.3 in Glioma Specimens.0
328250952020Multivalent and Bidirectional Binding of Transcriptional Transactivation Domains to the MED25 Coactivator.1
323243102020Further delineation of Basel-Vanagaite-Smirin-Yosef syndrome: Report of three patients.2
323675062020Analysis of P(78): A Novel Cytoplasmic Membrane-Associated Protein Encoded on Chromosome 19q13.3 in Glioma Specimens.0
328250952020Multivalent and Bidirectional Binding of Transcriptional Transactivation Domains to the MED25 Coactivator.1
272737872017Upregulation of human CYP2C9 expression by Bisphenol A via estrogen receptor alpha (ERα) and Med25.2
287289832017ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain.24
272737872017Upregulation of human CYP2C9 expression by Bisphenol A via estrogen receptor alpha (ERα) and Med25.2
287289832017ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain.24
274060342016Frameshift Mutation of MED25, a Transcription Regulator, and its Mutational Heterogeneity in Colorectal Cancers.0

Citation

Dessen P

MED25 (mediator complex subunit 25)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52109/case-report-explorer/img/logo-atlas-4.svg