GINS2 (GINS complex subunit 2)

2011-03-01  

Identity

HGNC
GINS2
LOCATION
16q24.1
LOCUSID
51659
ALIAS
HSPC037,PSF2,Pfs2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51659
MIM: 610609
HGNC: 24575
Ensembl: ENSG00000131153

Variants:

dbSNP: 51659
ClinVar: 51659
TCGA: ENSG00000131153
COSMIC: GINS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131153ENST00000253462Q9Y248
ENSG00000131153ENST00000595355M0R043
ENSG00000131153ENST00000596233M0QXS3

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
GINS complexKEGGhsa_M00286
GINS complexKEGGM00286
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Unwinding of DNAREACTOMER-HSA-176974
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
385177792024GINS2 promotes the progression of human HNSCC by altering RRM2 expression.0
385177792024GINS2 promotes the progression of human HNSCC by altering RRM2 expression.0
343538632022Biallelic GINS2 variant p.(Arg114Leu) causes Meier-Gorlin syndrome with craniosynostosis.8
351379282022GINS2 regulates the proliferation and apoptosis of colon cancer cells through PTP4A1.5
358960112022Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.4
343538632022Biallelic GINS2 variant p.(Arg114Leu) causes Meier-Gorlin syndrome with craniosynostosis.8
351379282022GINS2 regulates the proliferation and apoptosis of colon cancer cells through PTP4A1.5
358960112022Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.4
333894962021GINS2 was regulated by lncRNA XIST/miR-23a-3p to mediate proliferation and apoptosis in A375 cells.7
335378292021GINS2 affects cell proliferation, apoptosis, migration and invasion in thyroid cancer via regulating MAPK signaling pathway.3
342888162021MicroRNA miR-502-5p inhibits ovarian cancer genesis by downregulation of GINS complex subunit 2.8
346293652021GINS Complex Subunit 2 Facilitates Gastric Adenocarcinoma Proliferation and Indicates Poor Prognosis.4
333894962021GINS2 was regulated by lncRNA XIST/miR-23a-3p to mediate proliferation and apoptosis in A375 cells.7
335378292021GINS2 affects cell proliferation, apoptosis, migration and invasion in thyroid cancer via regulating MAPK signaling pathway.3
342888162021MicroRNA miR-502-5p inhibits ovarian cancer genesis by downregulation of GINS complex subunit 2.8

Citation

Dessen P

GINS2 (GINS complex subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52149/gins2