NEXN (nexilin F-actin binding protein)

NEXN (nexilin F-actin binding protein)

2011-03-01 Affiliation

Identity

HGNC

LOCATION

1p31.1

LOCUSID

ALIAS

CMH20,NELIN

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 91624
MIM: 613121
HGNC: 29557
Ensembl: ENSG00000162614

Variants:

dbSNP: 91624
ClinVar: 91624
TCGA: ENSG00000162614
COSMIC: NEXN

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000162614	ENST00000330010	Q0ZGT2
ENSG00000162614	ENST00000334785	Q0ZGT2
ENSG00000162614	ENST00000342754	H7BXY5
ENSG00000162614	ENST00000401035	E7ETM8
ENSG00000162614	ENST00000440324	E7EUA0

Expression (GTEx)

0

50

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38059363	2024	NEXN Gene in Cardiomyopathies and Sudden Cardiac Deaths: Prevalence, Phenotypic Expression, and Prognosis.	0
38059363	2024	NEXN Gene in Cardiomyopathies and Sudden Cardiac Deaths: Prevalence, Phenotypic Expression, and Prognosis.	0
35166435	2022	Loss of Nexilin function leads to a recessive lethal fetal cardiomyopathy characterized by cardiomegaly and endocardial fibroelastosis.	9
35166435	2022	Loss of Nexilin function leads to a recessive lethal fetal cardiomyopathy characterized by cardiomegaly and endocardial fibroelastosis.	9
33949776	2021	Childhood onset nexilin dilated cardiomyopathy: A heterozygous and a homozygous case.	10
33949776	2021	Childhood onset nexilin dilated cardiomyopathy: A heterozygous and a homozygous case.	10
30589415	2019	Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN.	72
31392414	2019	Whole genome and transcriptome sequencing of post-mortem cardiac tissues from sudden cardiac death victims identifies a gene regulatory variant in NEXN.	16
30589415	2019	Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN.	72
31392414	2019	Whole genome and transcriptome sequencing of post-mortem cardiac tissues from sudden cardiac death victims identifies a gene regulatory variant in NEXN.	16
30158653	2018	Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP.	12
30158653	2018	Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP.	12
26458985	2015	Regulatory mechanism of human vascular smooth muscle cell phenotypic transformation induced by NELIN.	6
26458985	2015	Regulatory mechanism of human vascular smooth muscle cell phenotypic transformation induced by NELIN.	6
24866383	2014	NEXN inhibits GATA4 and leads to atrial septal defects in mice and humans.	13

Citation

Dessen P

NEXN (nexilin F-actin binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52154/js/js/lib/jquery-3.5.1.min.js