VLDLR (very low density lipoprotein receptor)

2011-04-01  

Identity

HGNC
VLDLR
LOCATION
9p24.2
LOCUSID
7436
ALIAS
CAMRQ1,CARMQ1,CHRMQ1,VLDL-R,VLDLRCH

Other Information

Locus ID:

NCBI: 7436
MIM: 192977
HGNC: 12698
Ensembl: ENSG00000147852

Variants:

dbSNP: 7436
ClinVar: 7436
TCGA: ENSG00000147852
COSMIC: VLDLR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147852ENST00000382096Q5VVF8
ENSG00000147852ENST00000382099P98155
ENSG00000147852ENST00000382099Q5VVF5
ENSG00000147852ENST00000382100P98155

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
VLDL interactionsREACTOMER-HSA-8855121
VLDLR internalisation and degradationREACTOMER-HSA-8866427
Reelin signalling pathwayREACTOMER-HSA-8866376

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363522752022Identification of the miR-423-3p/VLDLR Regulatory Network for Glioma Using Transcriptome Analysis.0
363522752022Identification of the miR-423-3p/VLDLR Regulatory Network for Glioma Using Transcriptome Analysis.0
345094732021ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium.6
345094732021ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium.6
327110222020Expression level of VLDL receptor and VLDL-c levels in the malignant and benign breast tumors: The correlation with miRNA-4465 and miRNA-1297.4
327110222020Expression level of VLDL receptor and VLDL-c levels in the malignant and benign breast tumors: The correlation with miRNA-4465 and miRNA-1297.4
310785662019The VLDL receptor plays a key role in the metabolism of postprandial remnant lipoproteins.9
314052272019Association between SNPs of Circulating Vascular Endothelial Growth Factor Levels, Hypercholesterolemia and Metabolic Syndrome.7
310785662019The VLDL receptor plays a key role in the metabolism of postprandial remnant lipoproteins.9
314052272019Association between SNPs of Circulating Vascular Endothelial Growth Factor Levels, Hypercholesterolemia and Metabolic Syndrome.7
293716072018Degradation routes of trafficking-defective VLDLR mutants associated with Dysequilibrium syndrome.5
299657302018Nuclear Magnetic Resonance Solution Structure of the Recombinant Fragment Containing Three Fibrin-Binding Cysteine-Rich Domains of the Very Low Density Lipoprotein Receptor.4
293716072018Degradation routes of trafficking-defective VLDLR mutants associated with Dysequilibrium syndrome.5
299657302018Nuclear Magnetic Resonance Solution Structure of the Recombinant Fragment Containing Three Fibrin-Binding Cysteine-Rich Domains of the Very Low Density Lipoprotein Receptor.4
281124432017Decreased expression of VLDLR is inversely correlated with miR-200c in human colorectal cancer.5

Citation

Dessen P

VLDLR (very low density lipoprotein receptor)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52167