IK (IK cytokine)

2011-04-01  

Identity

HGNC
IK
LOCATION
5q31.3
LOCUSID
3550
ALIAS
CSA2,RED,RER
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3550
MIM: 600549
HGNC: 5958
Ensembl: ENSG00000113141

Variants:

dbSNP: 3550
ClinVar: 3550
TCGA: ENSG00000113141
COSMIC: IK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113141ENST00000417647Q13123
ENSG00000113141ENST00000502899D6REL4
ENSG00000113141ENST00000503332D6RAH1
ENSG00000113141ENST00000507593D6RAY9
ENSG00000113141ENST00000508301E7EQZ7
ENSG00000113141ENST00000513256D6RCQ4
ENSG00000113141ENST00000610522A0A0C4DGW5

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
342506292021IK: A novel cell mitosis regulator that contributes to carcinogenesis.0
342506292021IK: A novel cell mitosis regulator that contributes to carcinogenesis.0
310765552019Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.4
314097872019Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns.15
310765552019Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.4
314097872019Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns.15
269067152016IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells.5
269067152016IK-guided PP2A suppresses Aurora B activity in the interphase of tumor cells.5
252772672015Low-dose photon irradiation alters cell differentiation via activation of hIK channels.9
252772672015Low-dose photon irradiation alters cell differentiation via activation of hIK channels.9
249453532014Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing.28
249961882014Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases.9
249453532014Recruitment of RED-SMU1 complex by Influenza A Virus RNA polymerase to control Viral mRNA splicing.28
249961882014Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases.9
223517682012RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint.10

Citation

Dessen P

IK (IK cytokine)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52178