CLEC2B (C-type lectin domain family 2 member B)

2011-04-01  

Identity

HGNC
CLEC2B
LOCATION
12p13.31
LOCUSID
9976
ALIAS
AICL,CLECSF2,HP10085,IFNRG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9976
MIM: 603242
HGNC: 2053
Ensembl: ENSG00000110852

Variants:

dbSNP: 9976
ClinVar: 9976
TCGA: ENSG00000110852
COSMIC: CLEC2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110852ENST00000228438Q92478
ENSG00000110852ENST00000538152F5H631

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
359028262022Association between c-type lectin-like receptor 2 and microsatellite instability in colorectal cancer: a cross-sectional study.0
359028262022Association between c-type lectin-like receptor 2 and microsatellite instability in colorectal cancer: a cross-sectional study.0
312804682020Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease.11
312804682020Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease.11
299806092018Cellular Mechanisms Controlling Surfacing of AICL Glycoproteins, Cognate Ligands of the Activating NK Receptor NKp80.4
299806092018Cellular Mechanisms Controlling Surfacing of AICL Glycoproteins, Cognate Ligands of the Activating NK Receptor NKp80.4
279600392017Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners from in utero to adulthood.32
279600392017Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners from in utero to adulthood.32
254628182015C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets.3
264181602015Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.25
254628182015C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets.3
264181602015Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.25
239298562013Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses.22
239298562013Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses.22
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37

Citation

Dessen P

CLEC2B (C-type lectin domain family 2 member B)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52189