KLRD1 (killer cell lectin like receptor D1)

2011-04-01  

Identity

HGNC
KLRD1
LOCATION
12p13.2
LOCUSID
3824
ALIAS
CD94

Other Information

Locus ID:

NCBI: 3824
MIM: 602894
HGNC: 6378
Ensembl: ENSG00000134539

Variants:

dbSNP: 3824
ClinVar: 3824
TCGA: ENSG00000134539
COSMIC: KLRD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134539ENST00000336164Q13241
ENSG00000134539ENST00000344825E9PCX9
ENSG00000134539ENST00000350274Q13241
ENSG00000134539ENST00000381908Q13241
ENSG00000134539ENST00000539374F5GX94
ENSG00000134539ENST00000539792H0YFB8
ENSG00000134539ENST00000543420F5GX94
ENSG00000134539ENST00000543777F6WZH4
ENSG00000134539ENST00000544747F5H2B7

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Natural killer cell mediated cytotoxicityKEGGko04650
Graft-versus-host diseaseKEGGko05332
Antigen processing and presentationKEGGhsa04612
Natural killer cell mediated cytotoxicityKEGGhsa04650
Graft-versus-host diseaseKEGGhsa05332
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotationassociatedPD26453102
PA165107055certolizumab pegolChemicalClinicalAnnotationassociatedPD26453102
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD26453102
PA449515etanerceptChemicalClinicalAnnotationassociatedPD26453102
PA450428methotrexateChemicalClinicalAnnotationassociatedPD26453102
PA452347glucocorticoidsChemicalClinicalAnnotationassociatedPD26453102
PA452639infliximabChemicalClinicalAnnotationassociatedPD26453102

References

Pubmed IDYearTitleCitations
359245752023Early expression of CD94 and loss of CD96 on CD8+ T cells after allogeneic stem cell tranplantation is predictive of subsequent relapse and survival.1
359245752023Early expression of CD94 and loss of CD96 on CD8+ T cells after allogeneic stem cell tranplantation is predictive of subsequent relapse and survival.1
336157292021Reduced expansion of CD94/NKG2C(+) NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions.6
338872022021The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.31
339900032021CD94 expression patterns in reactive and neoplastic T-cell and NK-cell proliferations.1
342718752021KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease.7
336157292021Reduced expansion of CD94/NKG2C(+) NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions.6
338872022021The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.31
339900032021CD94 expression patterns in reactive and neoplastic T-cell and NK-cell proliferations.1
342718752021KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease.7
314098732020The inhibitory receptor CD94/NKG2A on CD8(+) tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression.36
325695192020HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity.40
325754032020NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain.14
314098732020The inhibitory receptor CD94/NKG2A on CD8(+) tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression.36
325695192020HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity.40

Citation

Dessen P

KLRD1 (killer cell lectin like receptor D1)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52201