ADGRE2 (adhesion G protein-coupled receptor E2)

2011-05-01  

Identity

HGNC
ADGRE2
LOCATION
19p13.12
LOCUSID
30817
ALIAS
CD312,CD97,EMR2,VBU

Other Information

Locus ID:

NCBI: 30817
MIM: 606100
HGNC: 3337
Ensembl: ENSG00000127507

Variants:

dbSNP: 30817
ClinVar: 30817
TCGA: ENSG00000127507
COSMIC: ADGRE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127507ENST00000315576Q9UHX3
ENSG00000127507ENST00000392962B4DWB8
ENSG00000127507ENST00000392965Q9UHX3
ENSG00000127507ENST00000594076Q9UHX3
ENSG00000127507ENST00000594294Q9UHX3
ENSG00000127507ENST00000595208M0QY55
ENSG00000127507ENST00000595839Q9UHX3
ENSG00000127507ENST00000596991Q9UHX3
ENSG00000127507ENST00000601345M0R0K5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080

References

Pubmed IDYearTitleCitations
379983922023The Posttraumatic Increase of the Adhesion GPCR EMR2/ADGRE2 on Circulating Neutrophils Is Not Related to Injury Severity.0
379983922023The Posttraumatic Increase of the Adhesion GPCR EMR2/ADGRE2 on Circulating Neutrophils Is Not Related to Injury Severity.0
334976052021Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.26
334976052021Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.26
319696682020G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody.12
322224572020Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2.9
334885982020Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes.5
319696682020G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody.12
322224572020Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2.9
334885982020Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes.5
304450642019Ordinary vibratory angioedema is not generally associated with ADGRE2 mutation.2
315946422019The role of the RGD motif in CD97/ADGRE5-and EMR2/ADGRE2-modulated tumor angiogenesis.6
304450642019Ordinary vibratory angioedema is not generally associated with ADGRE2 mutation.2
315946422019The role of the RGD motif in CD97/ADGRE5-and EMR2/ADGRE2-modulated tumor angiogenesis.6
295407352018Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation.3

Citation

Dessen P

ADGRE2 (adhesion G protein-coupled receptor E2)

Atlas Genet Cytogenet Oncol Haematol. 2011-05-01

Online version: http://atlasgeneticsoncology.org/gene/52210/case-report-explorer/js/lib/img/logo-atlas-4.svg