ADAR (adenosine deaminase RNA specific)

2011-05-01  

Identity

HGNC
ADAR
LOCATION
1q21.3
LOCUSID
103
ALIAS
ADAR1,AGS6,DRADA,DSH,DSRAD,G1P1,IFI-4,IFI4,K88DSRBP,P136
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 103
MIM: 146920
HGNC: 225
Ensembl: ENSG00000160710

Variants:

dbSNP: 103
ClinVar: 103
TCGA: ENSG00000160710
COSMIC: ADAR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160710ENST00000368471P55265
ENSG00000160710ENST00000368474P55265
ENSG00000160710ENST00000529168P55265
ENSG00000160710ENST00000648231P55265
ENSG00000160710ENST00000648311P55265
ENSG00000160710ENST00000648714A0A3B3ISX1
ENSG00000160710ENST00000648871A0A3B3ITG9
ENSG00000160710ENST00000649022A0A3B3IRQ9
ENSG00000160710ENST00000649042P55265
ENSG00000160710ENST00000649408A0A3B3ISU1
ENSG00000160710ENST00000649724P55265
ENSG00000160710ENST00000649749P55265

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: A to I ConversionREACTOMER-HSA-75064
Formation of editosomes by ADAR proteinsREACTOMER-HSA-77042
C6 deamination of adenosineREACTOMER-HSA-75102

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366833602024Enhanced mitophagy driven by ADAR1-GLI1 editing supports the self-renewal of cancer stem cells in HCC.4
377408602024Multi-dimensional Insight into the Coexistence of Pathogenic Genes for ADAR1 and TSC2: Careful Consideration is Essential for Interpretation of ADAR1 Variants.0
381695842024ADAR1 protects pulmonary macrophages from sepsis-induced pyroptosis and lung injury through miR-21/A20 signaling.1
381761702024ADAR-mediated RNA editing regulates PVR immune checkpoint in colorectal cancer.0
381907342024Impact of Disease-Associated Mutations on the Deaminase Activity of ADAR1.1
382659382024Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing.1
385301972024Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells.2
385316452024Multifaceted roles of RNA editing enzyme ADAR1 in innate immunity.0
386843072024[Analysis of ADAR gene variants in a Chinese pedigree affected with Dyschromatosis symmetrica hereditaria in conjunct with developmental delay].0
386969082024Exploration and Validation of Ferroptosis-Associated Genes in ADAR1 Deletion-Induced NAFLD through RNA-seq Analysis.0
387668532024Calreticulin regulates the expression of MMP14 and ADAR1 through EIF2AK2 signaling to promote the proliferation and progression of malignant melanoma cells.0
388209622024Dichotomous roles of ADAR1 in liver hepatocellular carcinoma and kidney renal cell carcinoma: Unraveling the complex tumor microenvironment and prognostic significance.0
366833602024Enhanced mitophagy driven by ADAR1-GLI1 editing supports the self-renewal of cancer stem cells in HCC.4
377408602024Multi-dimensional Insight into the Coexistence of Pathogenic Genes for ADAR1 and TSC2: Careful Consideration is Essential for Interpretation of ADAR1 Variants.0
381695842024ADAR1 protects pulmonary macrophages from sepsis-induced pyroptosis and lung injury through miR-21/A20 signaling.1

Citation

Dessen P

ADAR (adenosine deaminase RNA specific)

Atlas Genet Cytogenet Oncol Haematol. 2011-05-01

Online version: http://atlasgeneticsoncology.org/gene/52214