Identity
HGNC
LOCATION
8q12.1
LOCUSID
ALIAS
NCOA6IP,PIMT,PIPMT
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 96764
MIM: 606461
HGNC: 17843
Ensembl: ENSG00000137574
Variants:
dbSNP: 96764
ClinVar: 96764
TCGA: ENSG00000137574
COSMIC: TGS1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000137574 | ENST00000260129 | Q96RS0 |
| ENSG00000137574 | ENST00000523948 | E5RJW7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37751782 | 2024 | TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice. | 0 |
| 37751782 | 2024 | TGS1/PIMT knockdown reduces lipid accumulation in adipocytes, limits body weight gain and promotes insulin sensitivity in mice. | 0 |
| 35947650 | 2022 | TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration. | 5 |
| 35947650 | 2022 | TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration. | 5 |
| 32023455 | 2020 | Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation. | 26 |
| 32023455 | 2020 | Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation. | 26 |
| 26738492 | 2016 | The enzyme L-isoaspartyl (D-aspartyl) methyltransferase is required for VEGF-dependent endothelial cell migration and tubulogenesis. | 3 |
| 26738492 | 2016 | The enzyme L-isoaspartyl (D-aspartyl) methyltransferase is required for VEGF-dependent endothelial cell migration and tubulogenesis. | 3 |
| 26074133 | 2015 | Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing. | 4 |
| 26074133 | 2015 | Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing. | 4 |
| 23922881 | 2013 | PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2. | 7 |
| 23922881 | 2013 | PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2. | 7 |
| 21204776 | 2011 | Damaged proteins bearing L-isoaspartyl residues and aging: a dynamic equilibrium between generation of isomerized forms and repair by PIMT. | 34 |
| 21204776 | 2011 | Damaged proteins bearing L-isoaspartyl residues and aging: a dynamic equilibrium between generation of isomerized forms and repair by PIMT. | 34 |
| 20360394 | 2010 | Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing. | 17 |
Citation
Dessen P
TGS1 (trimethylguanosine synthase 1)
Atlas Genet Cytogenet Oncol Haematol. 2011-06-01
Online version: http://atlasgeneticsoncology.org/gene/52236/tgs1
