Identity
HGNC
LOCATION
5q31.3
LOCUSID
ALIAS
4E-BP3,4EBP3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8637
MIM: 603483
HGNC: 3290
Ensembl: ENSG00000243056
Variants:
dbSNP: 8637
ClinVar: 8637
TCGA: ENSG00000243056
COSMIC: EIF4EBP3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000243056 | ENST00000310331 | O60516 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| RNA transport | KEGG | ko03013 |
| RNA transport | KEGG | hsa03013 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31853750 | 2020 | eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/β-catenin in gastric cancer. | 1 |
| 31853750 | 2020 | eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/β-catenin in gastric cancer. | 1 |
| 29333098 | 2018 | MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis through Targeting the eIF4EBP3 Gene in Human Cervical Squamous Carcinoma Cells. | 23 |
| 29333098 | 2018 | MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis through Targeting the eIF4EBP3 Gene in Human Cervical Squamous Carcinoma Cells. | 23 |
| 27319316 | 2016 | Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3. | 20 |
| 27319316 | 2016 | Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3. | 20 |
| 22684010 | 2012 | 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2. | 3 |
| 22684010 | 2012 | 4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2. | 3 |
| 21088106 | 2011 | Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-β-signaling pathway. | 44 |
| 21088106 | 2011 | Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-β-signaling pathway. | 44 |
| 20621385 | 2010 | Prognostic significance of expression of eukaryotic initiation factor 4E and 4E binding protein 1 in patients with pathological stage I invasive lung adenocarcinoma. | 12 |
| 20621385 | 2010 | Prognostic significance of expression of eukaryotic initiation factor 4E and 4E binding protein 1 in patients with pathological stage I invasive lung adenocarcinoma. | 12 |
| 14507920 | 2003 | Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E. | 8 |
| 14557257 | 2003 | Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. | 28 |
| 14507920 | 2003 | Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E. | 8 |
Citation
Dessen P
EIF4EBP3 (eukaryotic translation initiation factor 4E binding protein 3)
Atlas Genet Cytogenet Oncol Haematol. 2011-06-01
Online version: http://atlasgeneticsoncology.org/gene/52256/eif4ebp3
