KRT4 (keratin 4)

2011-07-01  

Identity

HGNC
KRT4
LOCATION
12q13.13
LOCUSID
3851
ALIAS
CK-4,CK4,CYK4,K4,WSN1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3851
MIM: 123940
HGNC: 6441
Ensembl: ENSG00000170477

Variants:

dbSNP: 3851
ClinVar: 3851
TCGA: ENSG00000170477
COSMIC: KRT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170477ENST00000548097F8VX05
ENSG00000170477ENST00000551956P19013
ENSG00000170477ENST00000552668F8VZR6

Expression (GTEx)

0
5000
10000
15000
20000
25000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368110042023Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma.4
368110042023Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma.4
357079352022Negative regulation of miR-1288-3p/KRT4 axis through a circular RNA in oral cancer.0
365534512022White Sponge Nevus Caused by Keratin 4 Gene Mutation: A Case Report.1
357079352022Negative regulation of miR-1288-3p/KRT4 axis through a circular RNA in oral cancer.0
365534512022White Sponge Nevus Caused by Keratin 4 Gene Mutation: A Case Report.1
321249452020CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer.6
321249452020CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer.6
294766682018Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus.4
297386052018Keratin 4 regulates the development of human white sponge nevus.4
294766682018Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus.4
297386052018Keratin 4 regulates the development of human white sponge nevus.4
256031462015Structure of KRT4 binding domain of Srr-1 from Streptococcus agalactiae reveals a novel β-sheet complementation.4
256031462015Structure of KRT4 binding domain of Srr-1 from Streptococcus agalactiae reveals a novel β-sheet complementation.4
231826992013Mutation of keratin 4 gene causing white sponge nevus in a Japanese family.5

Citation

Dessen P

KRT4 (keratin 4)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52270/js/js/lib/teaching-explorer/