Identity
HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
L3,LASS2,SP260,TMSG1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29956
MIM: 606920
HGNC: 14076
Ensembl: ENSG00000143418
Variants:
dbSNP: 29956
ClinVar: 29956
TCGA: ENSG00000143418
COSMIC: CERS2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38191448 | 2024 | LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells. | 0 |
| 38191448 | 2024 | LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells. | 0 |
| 36946034 | 2023 | [LASS2/TMSG1 overexpression inhibits proliferation and promotes apoptosis of human lung cancer A549 cells possibly by upregulating ceramide and p38 MAPK to activate a signaling cascade]. | 0 |
| 36946034 | 2023 | [LASS2/TMSG1 overexpression inhibits proliferation and promotes apoptosis of human lung cancer A549 cells possibly by upregulating ceramide and p38 MAPK to activate a signaling cascade]. | 0 |
| 34915026 | 2022 | Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. | 4 |
| 35734966 | 2022 | Hsa-miR-221-3p promotes proliferation and migration in HER2-positive breast cancer cells by targeting LASS2 and MBD2. | 0 |
| 36300249 | 2022 | LASS2 overexpression enhances early apoptosis of lung cancer cells through the caspase‑dependent pathway. | 1 |
| 34915026 | 2022 | Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. | 4 |
| 35734966 | 2022 | Hsa-miR-221-3p promotes proliferation and migration in HER2-positive breast cancer cells by targeting LASS2 and MBD2. | 0 |
| 36300249 | 2022 | LASS2 overexpression enhances early apoptosis of lung cancer cells through the caspase‑dependent pathway. | 1 |
| 33423335 | 2021 | Ceramide synthase 2-C(24:1) -ceramide axis limits the metastatic potential of ovarian cancer cells. | 9 |
| 33515546 | 2021 | Ceramide synthase 2 deletion decreases the infectivity of HIV-1. | 11 |
| 33568634 | 2021 | Alternative splicing of ceramide synthase 2 alters levels of specific ceramides and modulates cancer cell proliferation and migration in Luminal B breast cancer subtype. | 11 |
| 33705551 | 2021 | Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study. | 5 |
| 34383404 | 2021 | MicroRNA-20a Targeting LASS2 Promotes the Proliferation, Invasiveness and Migration of Bladder Cancer. | 2 |
Citation
Dessen P
CERS2 (ceramide synthase 2)
Atlas Genet Cytogenet Oncol Haematol. 2011-07-01
Online version: http://atlasgeneticsoncology.org/gene/52300/cers2
