SRGN (serglycin)

2011-08-01  

Identity

HGNC
SRGN
LOCATION
10q22.1
LOCUSID
5552
ALIAS
PPG,PRG,PRG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5552
MIM: 177040
HGNC: 9361
Ensembl: ENSG00000122862

Variants:

dbSNP: 5552
ClinVar: 5552
TCGA: ENSG00000122862
COSMIC: SRGN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122862ENST00000242465P10124

Expression (GTEx)

0
500
1000
1500
2000
2500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381678072024Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration.2
384110262024miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin: Erratum.0
381678072024Serglycin secreted by late-stage nucleus pulposus cells is a biomarker of intervertebral disc degeneration.2
384110262024miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin: Erratum.0
345244272022SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas.16
349697352022Clinical Significance of Serglycin Expression in Human Breast Cancer Patients.0
345244272022SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas.16
349697352022Clinical Significance of Serglycin Expression in Human Breast Cancer Patients.0
330816792021Prognostic Significance of Hematopoietic-cell Serglycin for the Survival of Hepatocellular Carcinoma: A Single-center Retrospective Study.0
333143172021The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy.3
336349972021The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a β-catenin-dependent manner.3
345566362021Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone.8
330816792021Prognostic Significance of Hematopoietic-cell Serglycin for the Survival of Hepatocellular Carcinoma: A Single-center Retrospective Study.0
333143172021The relationship between plasma serglycin levels and the diagnosis of diabetic retinopathy.3
336349972021The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a β-catenin-dependent manner.3

Citation

Dessen P

SRGN (serglycin)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52326