SLU7 (SLU7 homolog, splicing factor)

2011-08-01  

Identity

HGNC
LOCATION
5q33.3
LOCUSID
ALIAS
9G8,hSlu7
FUSION GENES

Other Information

Locus ID:

NCBI: 10569
MIM: 605974
HGNC: 16939
Ensembl: ENSG00000164609

Variants:

dbSNP: 10569
ClinVar: 10569
TCGA: ENSG00000164609
COSMIC: SLU7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164609ENST00000297151O95391
ENSG00000164609ENST00000519349E5RGM7
ENSG00000164609ENST00000520664A0A0C4DGD2
ENSG00000164609ENST00000521826E5RK41

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
363621912022SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease.3
363621912022SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to Protein Stability in Health and Disease.3
341705692021Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.9
343314532021The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation.3
341705692021Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.9
343314532021The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation.3
306579572019Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins.37
306579572019Splicing events in the control of genome integrity: role of SLU7 and truncated SRSF3 proteins.37
298707422018Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice.6
298707422018Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice.6
268041742016Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression.16
268041742016Splicing regulator SLU7 preserves survival of hepatocellular carcinoma cells and other solid tumors via oncogenic miR-17-92 cluster expression.16
248654292014Splicing regulator SLU7 is essential for maintaining liver homeostasis.42
248654292014Splicing regulator SLU7 is essential for maintaining liver homeostasis.42
237547482013Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly.6

Citation

Dessen P

SLU7 (SLU7 homolog, splicing factor)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52328/slu7