Identity
HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
LIGOWS,MOF,MYST1,ZC2HC8,hMOF
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84148
MIM: 609912
HGNC: 17933
Ensembl: ENSG00000103510
Variants:
dbSNP: 84148
ClinVar: 84148
TCGA: ENSG00000103510
COSMIC: KAT8
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HATs acetylate histones | REACTOME | R-HSA-3214847 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38135180 | 2024 | Hotspot Cancer Mutation Impairs KAT8-mediated Nucleosomal Histone Acetylation. | 0 |
| 38411274 | 2024 | KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma. | 0 |
| 38135180 | 2024 | Hotspot Cancer Mutation Impairs KAT8-mediated Nucleosomal Histone Acetylation. | 0 |
| 38411274 | 2024 | KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma. | 0 |
| 37566546 | 2023 | MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC. | 0 |
| 37566546 | 2023 | MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC. | 0 |
| 35191804 | 2022 | Ropivacaine represses the proliferation, invasion, and migration of glioblastoma via modulating the microRNA-21-5p/KAT8 regulatory NSL complex subunit 2 axis. | 3 |
| 35191804 | 2022 | Ropivacaine represses the proliferation, invasion, and migration of glioblastoma via modulating the microRNA-21-5p/KAT8 regulatory NSL complex subunit 2 axis. | 3 |
| 33376138 | 2021 | Dysregulation of intercellular signaling by MOF deletion leads to liver injury. | 3 |
| 33467728 | 2021 | Substrate Scope for Human Histone Lysine Acetyltransferase KAT8. | 4 |
| 33544437 | 2021 | MOF upregulates the estrogen receptor α signaling pathway by its acetylase activity in hepatocellular carcinoma. | 8 |
| 33657400 | 2021 | Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis. | 32 |
| 34285225 | 2021 | TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy. | 27 |
| 33376138 | 2021 | Dysregulation of intercellular signaling by MOF deletion leads to liver injury. | 3 |
| 33467728 | 2021 | Substrate Scope for Human Histone Lysine Acetyltransferase KAT8. | 4 |
Citation
Dessen P
KAT8 (lysine acetyltransferase 8)
Atlas Genet Cytogenet Oncol Haematol. 2011-08-01
Online version: http://atlasgeneticsoncology.org/gene/52336/kat8
